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- Title
Multiple Primary Carcinomas with Esophageal Squamous Cell Cancer: Clinicopathologic Outcome.
- Authors
Natsugoe, Shoji; Matsumoto, Masataka; Okumura, Hiroshi; Ishigami, Sumiya; Uenosono, Yoshikazu; Owaki, Tetsuhiro; Takao, Sonshin; Aikou, Takashi
- Abstract
The incidence of multiple primary carcinomas (MPCs) associated with esophageal cancer has increased. The purpose of this study was to analyze clinicopathologic findings for MPC and for only esophageal cancer (OEC). Of 157 patients with MPCs, 60 had synchronous cancer and 97 metachronous cancer. Another 42 patients had antecedent esophageal cancer (AEC), and 55 patients had subsequent esophageal cancer (SEC). We retrospectively analyzed the findings for patients in these categories. The incidence of early-stage carcinoma was higher in patients with MPCs than in those with an OEC. Of patients with MPCs, those with metachronous cancer had a hither rate of early-stage carcinoma than those with synchronous cancer. The 5-year survival rates were not significantly different for MPC and OEC patients. Patients with metachronous cancer had a significantly better prognosis than those with synchronous cancer (p = 0.017); and in the metachronous cancer group the prognosis was significantly better for patients with AEC than for those with SEC (p = 0.0005). Meticulous follow-up after treatment of a first cancer should be required to delete other early-stage carcinomas.
- Subjects
SQUAMOUS cell carcinoma; ESOPHAGEAL cancer; ESOPHAGEAL surgery; ESOPHAGECTOMY; CANCER; PATHOLOGY
- Publication
World Journal of Surgery, 2005, Vol 29, Issue 1, p46
- ISSN
0364-2313
- Publication type
Article
- DOI
10.1007/s00268-004-7525-y