We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
The central role of nuclear factor-κB in mesangial cell activation.
- Authors
Massy, Ziad A.; Guijarro, Carlos; O’Donnell, Micheal P.; Kim, Youngki; Kashtan, Clifford E.; Egido, Jesús; Kasiske, Bertram L.; Keane, William F.
- Abstract
The central role of nuclear factor-kB in mesangial cell activation Background Nuclear factor-kBB (NF-kB) is a family of transcription factors that is recognized by the kB enhancer element. Numerous proinflammatory genes have binding sites for NF-kBB, and the products of these genes are an integral part of cellular activation and inflammatory response systems. Because there is a close relationship between NF-kB and mediators of cell activation, it is possible that a disruption of NF-kB–activating pathways may effectively influence mesangial cell activation. Methods We reviewed available studies related to both NF-kB and mesangial cells in order to provide evidence for the role of NF-kB in mesangial cell activation. Results Studies reported by this laboratory and others showed that various experimental maneuvers that modulate NF-kB activation result in a parallel modulation of proinflammatory molecule production in cultured mesangial cells. Likewise, the ability of the inhibitors of NF-kB activation to down-regulate the inflammatory response in animal models of renal disease has been recently demonstrated. Conclusions These data suggest a pivotal role of NF-kB in mesangial cell activation and designate it as an obvious target for the modulation of this activation. Studies are necessary to characterize the role of NF-kB in human renal injury.
- Subjects
NF-kappa B; TRANSCRIPTION factors; INFLAMMATION; KIDNEY diseases; DNA-binding proteins
- Publication
Kidney International, 1999, Vol 56, pS76
- ISSN
0085-2538
- Publication type
Article
- DOI
10.1046/j.1523-1755.1999.07119.x