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- Title
Clinical characteristics and prognostic factors of malignant tumors involving pterygopalatine fossa.
- Authors
Woo, Hyun‐Jae; Hwang, Peter H.; Kaplan, Michael J.; Choby, Garret
- Abstract
Background: To identify the clinical characteristics and prognostic factors of malignancies involving the pterygopalatine fossa (PPF). Methods: Fifty‐seven patients who underwent curative surgery for malignant tumor involving PPF were reviewed. Results: The rates for three‐year local control (LC), five‐year disease‐free survival (DFS) and five‐year overall survival (OS) were 55.4%, 34.5%, and 52.7%, respectively. Perineural invasion (PNI) of the maxillary nerve with facial numbness (symptomatic V2 PNI) (P =.04) and cranial involvement (P =.03) were predictors for poor OS. Symptomatic V2 PNI was also a significant predictor for poor LC (P =.05) and DFS (P =.03). Within the subgroup analysis of patients with pathologically confirmed V2 PNI, asymptomatic V2 PNI patients had significantly better LC (71.2% vs 31.8%, P =.05) and DFS (43.8% vs 17.3%, P =.05) compared to symptomatic patients. Conclusion: Malignant tumors involving the PPF have diverse pathologies and a poor prognosis. Symptomatic V2 PNI may be an independent poor prognostic factor.
- Subjects
CANCER; MAXILLARY nerve; FACIAL nerve; PROGRESSION-free survival; TUMOR surgery
- Publication
Head & Neck, 2020, Vol 42, Issue 2, p281
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.26000