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- Title
Impact of smoking cessation on clinical outcomes in patients with head and neck squamous cell carcinoma receiving curative chemoradiotherapy: A prospective study.
- Authors
Chen, Jenny Ling‐Yu; Shen, Chia‐Wei; Wang, Chia‐Chun; Huang, Yu‐Sen; Chen, Jo‐Pai; Chiang, Chien‐Hsieh; Lin, Yu‐Li; Kuo, Sung‐Hsin; Wang, Chun‐Wei
- Abstract
Background: We hypothesized that patients with head and neck squamous cell carcinoma (HNSCC) with smoking cessation during curative chemoradiotherapy (CRT) had fewer complications and lower tumor progression risks. Methods: Sixty‐three patients with nonmetastatic HNSCC who were smokers at diagnosis (carbon monoxide [CO] breath concentrations ≥3 ppm) and underwent curative CRT were prospectively enrolled. Successful smoking cessation throughout CRT was confirmed by CO breath concentrations <3 ppm at CRT completion. Results: Forty‐one patients (65%) successfully discontinued smoking throughout CRT. With a median 33‐month follow‐up, patients with successful smoking cessation during CRT had significantly fewer, greater, and lower probabilities of grade ≥3 acute toxicities (P = .01), progression‐free survival (P = .03), and permanent gastrostomy or tracheostomy (P = .04), respectively, than those continuing smoking throughout CRT. In multivariate analysis, successful smoking cessation during CRT significantly reduced tumor progression risks (hazard ratio: 0.4, P = .05). Conclusion: Smoking cessation during curative CRT reduced treatment‐related toxicities and tumor progression risks in patients with HNSCC.
- Subjects
SMOKING cessation; CHEMORADIOTHERAPY; SQUAMOUS cell carcinoma; RECTAL cancer; LONGITUDINAL method; CANCER invasiveness; CARBON monoxide
- Publication
Head & Neck, 2019, Vol 41, Issue 9, p3201
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.25814