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- Title
Pretreatment count of peripheral neutrophils, monocytes, and lymphocytes as independent prognostic factor in patients with head and neck cancer.
- Authors
Valero, Cristina; Pardo, Laura; López, Montserrat; García, Jacinto; Camacho, Mercedes; Quer, Miquel; León, Xavier
- Abstract
Background The purpose of this study was to analyze the prognostic value of pretreatment count of peripheral neutrophils, lymphocytes, monocytes, and neutrophil-to-lymphocyte ratio (NLR) in patients with head and neck squamous cell carcinoma (HNSCC). Methods Local, regional, and distant recurrence-free survival and disease-specific survival were analyzed according to the count of neutrophils, lymphocytes, monocytes, and NLR. Results We observed a decrease in disease-specific survival as the quartile category of neutrophils, monocytes, and NLR increased. In the case of lymphocytes, patients in the lower quartile had lower disease-specific survival. Considering the disease-specific survival as the dependent variable, a recursive partitioning analysis classified the patients according to the neutrophil and monocyte counts. Conclusion High pretreatment count of peripheral neutrophils and/or monocytes was independently related with worse prognosis in patients with HNSCC. Classification based on pretreatment neutrophil and monocyte counts enabled the identification of different prognostic profiles. © 2016 Wiley Periodicals, Inc. Head Neck 39: 219-226, 2017
- Subjects
HEAD &; neck cancer treatment; HEAD &; neck cancer; BLOOD cell count; MONOCYTES; NEUTROPHILS; PROGNOSIS
- Publication
Head & Neck, 2017, Vol 39, Issue 2, p219
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24561