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- Title
Immortalization of epithelial cells in oral carcinogenesis as revealed by genome-wide array comparative genomic hybridization: A meta-analysis.
- Authors
Vincent–Chong, Vui King; Salahshourifar, Iman; Razali, Rozaimi; Anwar, Arif; Zain, Rosnah Binti
- Abstract
Background This purpose of this meta-analysis study was to identify the most frequent and potentially significant copy number alteration (CNA) in oral carcinogenesis. Methods Seven oral squamous cell carcinoma (OSCC)-related publications, corresponding to 312 samples, were identified for this meta-analysis. The data were analyzed in a 4-step process that included the genome assembly coordination of multiple platforms, assignment of chromosomal position anchors, calling gains and losses, and functional annotation analysis. Results Gains were more frequent than losses in the entire dataset. High-frequency gains were identified in chromosomes 5p, 14q, 11q, 7p, 17q, 20q, 8q, and 3q, whereas high-frequency losses were identified in chromosomes 3p, 8p, 6p, 18q, and 4q. Ingenuity pathway analysis showed that the top biological function was associated with immortalization of the epithelial cells ( p = 1.93E-04). Conclusion This study has identified multiple recurrent CNAs that are involved in various biological annotations associated with oral carcinogenesis. © 2015 Wiley Periodicals, Inc. Head Neck 38: E783-E797, 2016
- Subjects
ORAL cancer; EPITHELIAL cells; SQUAMOUS cell carcinoma; CARCINOGENESIS; HUMAN chromosomes
- Publication
Head & Neck, 2016, Vol 38, pE783
- ISSN
1043-3074
- Publication type
Article
- DOI
10.1002/hed.24102