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- Title
Effects of hypoxia and hyperoxia on the differential expression of VEGF-A isoforms and receptors in Idiopathic Pulmonary Fibrosis (IPF).
- Authors
Barratt, Shaney L.; Blythe, Thomas; Ourradi, Khadija; Jarrett, Caroline; Welsh, Gavin I.; Bates, David O.; Millar, Ann B.
- Abstract
Dysregulation of VEGF-A bioavailability has been implicated in the development of lung injury/fibrosis, exemplified by Idiopathic Pulmonary Fibrosis (IPF). VEGF-A is a target of the hypoxic response via its translational regulation by HIF-1α. The role of hypoxia and hyperoxia in the development and progression of IPF has not been explored. In normal lung (NF) and IPF-derived fibroblasts (FF) VEGF-Axxxa protein expression was upregulated by hypoxia, mediated through activation of VEGF-Axxxa gene transcription. VEGF-A receptors and co-receptors were differentially expressed by hypoxia and hyperoxia. Our data supports a potential role for hypoxia, hyperoxia and VEGF-Axxxa isoforms as drivers of fibrogenesis.
- Subjects
HYPEROXIA; VASCULAR endothelial growth factors; IDIOPATHIC pulmonary fibrosis; BIOCHEMISTRY; CELL culture; CELL physiology; CELL receptors; FIBROBLASTS; GENE expression; LUNGS; PHENOMENOLOGY; PROTEINS; RESEARCH funding; PHYSIOLOGY
- Publication
Respiratory Research, 2018, Vol 19, p1
- ISSN
1465-9921
- Publication type
letter
- DOI
10.1186/s12931-017-0711-x