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- Title
Diverse mechanisms and machineries for import of mitochondrial proteins.
- Authors
Milenkovic, Dusanka; Müller, Judith; Stojanovski, Diana; Pfanner, Nikolaus; Chacinska, Agnieszka
- Abstract
Mitochondria are ubiquitous organelles that play an essential role in energy conversion and biosynthetic pathways in eukaryotic cells. Most mitochondrial proteins must be imported from the cytosol and sorted into one of the four mitochondrial subcompartments, the outer membrane, the intermembrane space, the inner membrane and the matrix. Studies in recent years revealed a remarkable diversity of mechanisms and machineries that are required for the import of proteins into mitochondria. At least four different pathways for the sorting and assembly of nuclear-encoded mitochondrial proteins have been identified.
- Subjects
MITOCHONDRIA; EUKARYOTIC cells; CYTOSOL; ORGANELLES; PROTOPLASM
- Publication
Biological Chemistry, 2007, Vol 388, Issue 9, p891
- ISSN
1431-6730
- Publication type
Article
- DOI
10.1515/BC.2007.097