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- Title
The transmembrane protein, Tincar, is involved in the development of the compound eye inDrosophila melanogaster.
- Authors
Hirota, Yuki; Sawamoto, Kazunobu; Takahashi, Kuniaki; Ueda, Ryu; Okano, Hideyuki
- Abstract
We previously cloned and characterized theDrosophilagene,tincar(tinc), which encodes a novel protein with eight putative transmembrane domains. Here, we have studied the expression pattern and functions oftincduring developmental processes.tincmRNA is expressed in the central and peripheral nervous systems, and midgut during embryogenesis. In the third-instar larval eye disc,tincmRNA is strongly expressed in all the differentiating ommatidial cells within and in the vicinity of the morphogenetic furrow. Loss-of-function analysis using the RNA-interference method revealed severe defects of eye morphogenesis during the late developmental stages. Our results suggested thattincmay have an indispensable role in the normal differentiation of ommatidial cells.
- Subjects
DROSOPHILA melanogaster; MEMBRANE proteins; EYE; DEVELOPMENTAL biology; CELL differentiation; EMBRYOLOGY
- Publication
Development Genes & Evolution, 2005, Vol 215, Issue 2, p90
- ISSN
0949-944X
- Publication type
Article
- DOI
10.1007/s00427-004-0452-y