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- Title
Cytotoxic Triterpene from Barringtonia asiatica.
- Authors
Ragasa, Consolacion; Espineli, Dinah; Shen, Chien-Chang
- Abstract
Triterpenes isolated from the dichloromethane extract of Barringtonia asiatica, namely, a mixture of betulinic acid ( 1) and 22- O-tigloylcamelliagenin A ( 2) in a 1 : 2 ratio and a mixture of 3β-olean-18-en-3-yl palmitate ( 7), 3β-urs-12-en-3-yl palmitate ( 8) and 3β-olean-12-en-3-yl palmitate ( 9) in a 4 : 1 : 2 ratio (isolated from the bark), as well as germanicol caffeoyl ester ( 3), germanicol trans-coumaroyl ester ( 4), germanicol cis-coumaroyl ester ( 5) and germanicol ( 6) (from the leaves), and a phenolic compound, verimol K ( 10) from the flowers, were assessed for cytotoxicity against a human cancer cell line, colon carcinoma (HCT 116), using the MTT assay. The mixture of 1 and 2 exhibited IC =8.0 μg · mL against this cell line, while 6 exhibited an IC value of 29.6 μg · mL. The other compounds tested ( 3 - 5, 7 - 10) were inactive against the HCT 116 cell line. The mixture of 1 and 2 and compound 6 were further tested for cytotoxicity against the non-small cell lung adenocarcinoma (A549) cell line. The mixture of 1 and 2 and compound 6 exhibited IC values of 6.0 and 35.6 μg · mL, respectively. The cytotoxicity for the mixture of 1 and 2 may be attributed to betulinic acid ( 1), a known cytotoxic compound.
- Subjects
LECYTHIDACEAE; TRITERPENES; MIXTURE analysis; DICHLOROMETHANE; CELL-mediated cytotoxicity; BIOLOGICAL assay
- Publication
Pharmaceutical Chemistry Journal, 2014, Vol 48, Issue 8, p529
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-014-1144-1