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- Title
Synthesis and analgesic and antimicrobial activity of 2-aroylcyclohexanones and 3-aryl-4,5,6,7-tetrahydro-2,1-benzisoxazoles.
- Authors
Pantyukhin, A.; Pershina, N.; Balandina, S.; Aleksandrova, G.; Makhmudov, R.; Mikhailovskii, A.
- Abstract
A series of 2-aroylcyclohexanones were synthesized via acylation of 1-piperidinocyclohexene by aroylchlorides. The obtained 1,3-diketones reacted with hydroxylamine to yield 3-aryl-4,5,6,7-tetrahydro-2,1-benzisoxazoles. The starting 1,3-diketones and corresponding benzisoxazoles showed analgesic activity that exceeded that of metamizole sodium. Both groups of compounds exhibited weak activity against Candida albicans.
- Subjects
ANALGESICS; ANTI-infective agents; OXAZOLES; HEXANOLS; KETONES; HYDROXYLAMINE
- Publication
Pharmaceutical Chemistry Journal, 2013, Vol 47, Issue 4, p195
- ISSN
0091-150X
- Publication type
Article
- DOI
10.1007/s11094-013-0925-2