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- Title
Efficiently finding genome-wide three-way gene interactions from transcript- and genotype-data.
- Authors
Kayano, Mitsunori; Takigawa, Ichigaku; Shiga, Motoki; Tsuda, Koji; Mamitsuka, Hiroshi
- Abstract
Motivation: We address the issue of finding a three-way gene interaction, i.e. two interacting genes in expression under the genotypes of another gene, given a dataset in which expressions and genotypes are measured at once for each individual. This issue can be a general, switching mechanism in expression of two genes, being controlled by categories of another gene, and finding this type of interaction can be a key to elucidating complex biological systems. The most suitable method for this issue is likelihood ratio test using logistic regressions, which we call interaction test, but a serious problem of this test is computational intractability at a genome-wide level.
- Subjects
GENOMES; GENETIC transcription; GENE expression; SYSTEMS biology; COMPUTATIONAL biology
- Publication
Bioinformatics, 2009, Vol 25, Issue 21, p2735
- ISSN
1367-4803
- Publication type
Article
- DOI
10.1093/bioinformatics/btp531