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- Title
Standardizing Chemical Peel Solution Formulations to Avoid Mishaps.
- Authors
Bridenstine, James B.; Dolezal, James F.
- Abstract
BACKGROUND. <em>Chemical peeling using trichloroacetic acid (TCA) is a popular and long utilized procedure in dermatology and cosmetic surgery</em>. OBJECTIVE. <em>To determine the actual concentration of TCA in four disparate methods of preparation of solutions, expressed in the standard pharmaceutical method of weight to volume (wt/vol)</em>. METHODS. <em>Method I was wt/vol, method II was weight to weight (wt/wt), method III was grams of TCA added to 100 cc water, and method IV was the usage of saturated TCA, and calling it 100%, then making appropriate dilutions. The amounts of TCA in each solution for methods II, III, and IV were converted, by calculation, to the wt/vol method</em>. RESULTS. <em>The relative concentrations of TCA, ranked by the wt/vol pharmaceutical standard, showed that from strongest to weakest: method IV > method II > method I > method III</em>. CONCLUSIONS. <em>Tremendous variations were found in the relative concentrations of TCA in these solutions. To avoid mishaps and complications, the wt/vol method should be used</em>.
- Subjects
DERMATOLOGY; CHEMICAL peel; PLASTIC surgery; DERMATOLOGIC surgery; DERMABRASION; CHLOROACETIC acids
- Publication
Journal of Dermatologic Surgery & Oncology, 1994, Vol 20, Issue 12, p813
- ISSN
0148-0812
- Publication type
Article
- DOI
10.1111/j.1524-4725.1994.tb03710.x