We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Cannabinoid Therapeutic Effects in Inflammatory Bowel Diseases: A Systematic Review and Meta-Analysis of Randomized Controlled Trials.
- Authors
Vinci, Antonio; Ingravalle, Fabio; Bardhi, Dorian; Cesaro, Nicola; Frassino, Sara; Licata, Francesca; Valvano, Marco
- Abstract
(1) Introduction: Inflammatory Bowel Disease (IBD) patients may benefit from cannabinoid administration supplementary therapy; currently no consensus on its effect has been reached. (2) Methods: a systematic review of RCTs on cannabinoid supplementation therapy in IBD has been conducted; data sources were MEDLINE, Scopus, ClinicalTrials. (3) Results: out of 974 papers found with electronic search, six studies have been included into the systematic review, and five of them, for a grand total of 208 patients, were included into the meta-analysis. (4) Conclusions: cannabinoid supplementation as adjuvant therapy may increase the chances of success for standard therapy of Crohn's Disease during the induction period; no statement on its potential usage during maintenance period can be derived from retrieved evidence. Its usage in Ulcerative Colitis is not to be recommended. If ever, low-dose treatment may be more effective than higher dosage. Mean CDAI reduction was found stronger in patients treated with cannabinoids (mean CDAI reduction = 36.63, CI 95% 12.27–61.19) than placebo. In future studies, it is advisable to include disease activity levels, as well as patient-level information such as genetic and behavioral patterns.
- Subjects
INFLAMMATORY bowel diseases; CROHN'S disease; RANDOMIZED controlled trials; TREATMENT effectiveness; ULCERATIVE colitis
- Publication
Biomedicines, 2022, Vol 10, Issue 10, pN.PAG
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10102439