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- Title
Paradoxical Hidradenitis Suppurativa during Biologic Therapy, an Emerging Challenge: A Systematic Review.
- Authors
Ruggiero, Angelo; Martora, Fabrizio; Picone, Vincenzo; Marano, Laura; Fabbrocini, Gabriella; Marasca, Claudio
- Abstract
Hidradenitis suppurativa (HS) is a chronic, inflammatory skin disease usually occurring after puberty with painful, deep-seated, inflammatory lesions in the apocrine gland-bearing areas of the body. Although HS pathogenesis is still unproven, recent major research advantages have increased our knowledge of the mechanisms behind HS lesions. Particularly, follicular occlusion followed by follicular rupture has been shown to be crucial to HS development, leading to immune response activation, and resulting in typical clinical HS lesions. Moreover, an increased and imbalanced cytokine production, such as interleukin (IL) 17 and tumor necrosis factor (TNF) α, may play a role in HS. In recent years, paradoxical adverse events have been described during treatment. Since the recent increased use of biologic treatments in HS, an increased number of paradoxical HS occurrences have been reported. In this review, we analyzed all current data on paradoxical HS triggered by biological drugs.
- Subjects
HIDRADENITIS suppurativa; BIOTHERAPY; TUMOR necrosis factors; SKIN diseases
- Publication
Biomedicines, 2022, Vol 10, Issue 2, p455
- ISSN
2227-9059
- Publication type
Article
- DOI
10.3390/biomedicines10020455