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- Title
Reduction of Trifluoromethyl-containing 4-Nitroso- and 4-Arylazopyrazoles as a Method for 4-Amino-3-trifluoromethylpyrazoles Synthesis.
- Authors
Elkina, N. A.; Perminova, A. N.; Agafonova, N. A.; Shchegolkov, E. V.; Burgart, Ya. V.; Pervova, M. G.; Samorukova, M. A.; Saloutin, V. I.
- Abstract
The processes of 4-nitroso-3-trifluoromethylpyrazoles reduction under various conditions were studied. It was found that their reduction with zinc in acetic acid results in the formation of 4-aminopyrazole in a mixture with 4-bisazo- and 4-bisazoxypyrazoles. The optimal method for the synthesis of 4-amino-3-trifluoromethylpyrazoles consists in the 5–6 h hydrogenation of 4-nitrosopyrazoles under pressure (p 10 atm) in the presence of a Pd/C catalyst at 50°С in ethanol. It was shown that 4-arylazopyrazoles can be used for the synthesis of 4-aminopyrazoles by catalytic hydrogenation reactions.
- Subjects
ACETIC acid; HYDROGENATION; CATALYTIC hydrogenation; ZINC; AUTOMATED teller machines; MIXTURES
- Publication
Russian Journal of General Chemistry, 2022, Vol 92, Issue 9, p1591
- ISSN
1070-3632
- Publication type
Article
- DOI
10.1134/S107036322209002X