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- Title
Comparison of histopathological characteristics of allograft biopsy between responder and non-responder to antiproteinuric effect of angiotensin-converting enzyme inhibitor (ACEI).
- Authors
Namba, Y.; Moriyama, T.; Kyo, M.; Oka, K.; Kokado, Y.; Shi, Y.; Imamura, R.; Ichimaru, N.; Okuyama, A.; Takahara, S.
- Abstract
Namba Y, Moriyama T, Kyo M, Oka K, Kokado Y, Shi Y, Imamura R, Ichimaru N, Okuyama A and Takahara S. Comparison of histopathological characteristics of allograft biopsy between responder and non-responder to antiproteinuric effect of angiotensin-converting enzyme inhibitor (ACEI) Clin Transplant 2004: 18 (Suppl. 11): 29–33. © Blackwell Munksgaard, 2004 Angiotensin-converting enzyme inhibitor (ACEI) has become recognized as agents that have renoprotective effects in the treatment of progressive renal diseases including post-transplant kidneys. Previously we demonstrated the safety and effectiveness of ACEI treatment on the hypertensive proteinuric post-transplant patients ( N = 10) who had been followed up for 12 months. However, not all patients show good response in urinary protein reduction. We aimed to analyse the histopathological factor(s) affecting the responsiveness of proteinuria to ACEI treatment. Fourteen post-transplant patients with proteinuria who were treated with ACEI and underwent allograft biopsy were analysed. Eight patients showed 50% or more reduction in proteinuria (responder). The other 6 patients showed less (< 50%) reduction in proteinuria (non-responder). There was no difference in clinical characteristics (BP, renal function, donor age, recipient body mass index), dietary sodium or protein intake, and diuretic use between the two groups. As a histopathological characteristic, glomerular size in responder group was significantly larger than that in non-responder group. This suggests that the large glomerular size at least partly contributes to the responsiveness in urinary protein reduction to ACEI treatment in kidney allograft recipients with proteinuria.
- Subjects
ACE inhibitors; KIDNEY transplantation; PROTEINURIA; HOMOGRAFTS; BIOPSY
- Publication
Clinical Transplantation, 2004, Vol 18, p29
- ISSN
0902-0063
- Publication type
Article
- DOI
10.1111/j.1399-0012.2004.00244.x