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- Title
Molecular aspects of ischaemic postconditioning.
- Authors
Kaur, Shaminder; Jaggi, Amteshwar Singh; Singh, Nirmal
- Abstract
Preconditioning, a well established phenomenon had been used since 1980s to attenuate ischaemia-reperfusion induced injury. However, inability to predict the onset of ischaemia in clinical settings led to the discovery of a new concept of postconditioning (PoCo), in 2000s whereby brief repetitive cycles of ischaemia with intermittent reperfusion followed by prolonged ischaemia-elicited tissue protection. There is an impressive array of molecular mechanisms contributing to PoCo-mediated tissue-protection, which include triggers like adenosine (ADO), opioid, erythropoietin (EPO), endogenous nitric-oxide, reactive oxygen species, acetylcholine, tissue factors, pro-inflammatory cytokines and bradykinin; mediators like reperfusion injury salvage kinase pathways including phosphoinositide-3-kinase, extra-cellular signal regulated kinase½ pathway, protein kinase G and protein kinase C; end-effectors like mitohondrial permeability transition pore and mitochondrial potassium ATP channel. The clinical applicability of PoCo has been extended with the use of PoCo mimetic agents like insulin, glucagon like peptide, EPO, statins and ADO before reperfusion in patients with ischaemia reperfusion injury. Remote PoCo has also emerged as a new concept; however, considerable research is required for understanding its molecular mechanisms. In this review, an exhaustive attempt has been made to unearth some molecular aspects of PoCo.
- Subjects
ISCHEMIA; REPERFUSION; BLOOD circulation disorders; ADENOSINE triphosphate; IMMUNOREGULATION
- Publication
Fundamental & Clinical Pharmacology, 2009, Vol 23, Issue 5, p521
- ISSN
0767-3981
- Publication type
Article
- DOI
10.1111/j.1472-8206.2009.00733.x