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- Title
Role of Real-World Data in Assessing Cardiac Toxicity After Lung Cancer Radiotherapy.
- Authors
Abravan, Azadeh; Price, Gareth; Banfill, Kathryn; Marchant, Tom; Craddock, Matthew; Wood, Joe; Aznar, Marianne C.; McWilliam, Alan; van Herk, Marcel; Faivre-Finn, Corinne
- Abstract
Radiation-induced heart disease (RIHD) is a recent concern in patients with lung cancer after being treated with radiotherapy. Most of information we have in the field of cardiac toxicity comes from studies utilizing real-world data (RWD) as randomized controlled trials (RCTs) are generally not practical in this field. This article is a narrative review of the literature using RWD to study RIHD in patients with lung cancer following radiotherapy, summarizing heart dosimetric factors associated with outcome, strength, and limitations of the RWD studies, and how RWD can be used to assess a change to cardiac dose constraints.
- Subjects
CARDIOTOXICITY; LUNG cancer; CANCER radiotherapy; HEART diseases; RANDOMIZED controlled trials
- Publication
Frontiers in Oncology, 2022, Vol 12, p1
- ISSN
2234-943X
- Publication type
Article
- DOI
10.3389/fonc.2022.934369