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- Title
Evolution of the MIP family of integral membrane transport proteins.
- Authors
Pao, G. M.; Wu, L.-F.; Johnson, K. D.; Höfte, H.; Chrispeels, M. J.; Sweet, G.; Sandal, N. N.; Saier Jr., M. H.
- Abstract
Six integral membrane proteins of bacterial, animal, and plant origin, which are believed to function in solute transport, share sequence identity and are grouped together as members of the MIP family. These include the <em>Escherichia coli</em> glycerol facilitator, the major intrinsic protein from bovine lens fibre junction membranes, a plant tonoplast membrane protein, a soybean protein from the peribacteroid membrane, and a <em>Drosophila</em> neurogenic protein. These proteins, each of which appears to consist of six transmembrane helical segments per subunit, apparently arose by internal duplication of a three-trans-membrane segment. Phylogenetic 'trees' interrelating these proteins and segments are presented.
- Subjects
MEMBRANE proteins; ESCHERICHIA coli; ESCHERICHIA; GLYCERYL ethers; TONOPLASTS
- Publication
Molecular Microbiology, 1991, Vol 5, Issue 1, p33
- ISSN
0950-382X
- Publication type
Article
- DOI
10.1111/j.1365-2958.1991.tb01823.x