We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Ideal or actual body weight to calculate CD34+ cell doses for autologous hematopoietic stem cell transplantation?
- Authors
Ali, M Y; Oyama, Y; Monreal, J; Winter, J N; Tallman, M S; Williams, S F; Singhal, S; Gordon, L I; Mehta, J
- Abstract
Summary:The number of CD34+ cells infused influences the speed of hematologic recovery post-transplant. There are limited data on whether ideal (IBW) or actual (ABW) body weight should be used to calculate CD34+ cell dose. We compared the correlation between recovery to 0.5 x 109/l neutrophils and the CD34+ cell dose based upon ABW as well as IBW in 87 patients autografted for cancer. ABW was ?25% over IBW in 43% of patients. The median number of CD34+ cells administered was 3.6 x 106/kg ABW and 4.2 x 106/kg IBW. The time to neutrophil recovery was 8-15 days (median 10). There was a stronger inverse correlation between CD34+ cell dose/IBW and neutrophil recovery (r2=0.308; P<0.0001) than between CD34+ cell dose/ABW and neutrophil recovery (r2=0.267; P<0.0001). The median time to neutrophil recovery was comparable for those receiving ?2 x 106/kg CD34+ cells/kg IBW as well as ABW (10 days) and those receiving ?2 x 106/kg CD34+ cells/kg IBW but <2/kg ABW (10 days), but was significantly slower for those receiving <2 x 106/kg CD34+ cells/kg IBW (12 days). These data show that the CD34+ cell dose based on IBW is a better predictor of neutrophil recovery after autotransplantation.Bone Marrow Transplantation (2003) 31, 861-864. doi:10.1038/sj.bmt.1703955
- Subjects
CD antigens; HEMATOPOIETIC stem cell transplantation; AUTOTRANSPLANTATION
- Publication
Bone Marrow Transplantation, 2003, Vol 31, Issue 10, p861
- ISSN
0268-3369
- Publication type
Article
- DOI
10.1038/sj.bmt.1703955