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- Title
Prospects and genesis of the versatile antiparasitic drug Ivermectin and its unsurpassed beneficial impact in Human and Veterinary Medicine.
- Authors
M. M., Rahman; A., Kabir; M. K., Islam; M. S., Rahman; M. S., Yasmin; F., Alom; M. A., Islam; S., Ahmed; M. R., Islam; M. H., Islam
- Abstract
Ivermectin is a naturally-derived dihydro derivative of avermectin originating exclusively from a single microorganism isolated from Japanese soil displaying an exceptionally wide range of antiparasitic efficacy against internal and external parasites of human and domestic animals. At the outset introduced as veterinary drugs of commercial livestock and companion animals but it was quickly discovered to be ideal in tackling two of the world's most distressing and disfiguring diseases such as river blindness and elephantiasis which have besieged African countries for centuries. The kinetics of ivermectin is characterized in general terms by a slow absorption process, a broad distribution in the organism, low metabolism, and slow excretion. The pharmacokinetic parameters of ivermectin vary extensively and in accordance with many factors that can all influence the drug's plasma concentration. These factors, which include the animal species, route of administration, vehicle used in the commercial formulation, bodyweight, body condition, age, physiological status, and amount and type of nutrition, all of which contribute to differences in drug efficacy. Currently, ivermectin is one of the most important drugs for the control of endectoparasitic infection in human and veterinary medicine and was the joint focus of the 2015 Nobel Prize, some 3 decades after its remarkable discovery. Although best described for its activity on glutamate-gated chloride channels in parasites, understanding much of its therapeutic mechanism and wide array of novel targets remains to be elucidated. Today, ivermectin is continuing to surprise and excite scientists, with an extensive use and an enormous success as well as showing novel promise against a diverse range of human and animal diseases round the globe.
- Subjects
IVERMECTIN; VETERINARY medicine; DOMESTIC animals
- Publication
International Journal of Natural Sciences, 2017, Vol 6, Issue 3, p132
- ISSN
2221-1012
- Publication type
Article