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- Title
Plasma Copper and Zinc Concentration in Individuals with Autism Correlate with Selected Symptom Severity.
- Authors
Russo, Anthony J.; Bazin, Andrea P.; Bigega, Richard; Carlson III, Robert S.; Cole, Martin G.; Contreras, Dilenia C.; Galvin, Matthew B.; Gaydorus, Sayde S.; Holik, Sierra D.; Jenkins, Gavin P.; Jones, Brandon M.; Languell, Penelope A.; Lyman, Padraic J.; March, Kareem P.; Meuer, Katie A.; Peterson, Serena R.; Piedmonte, Matthew T.; Quinn, Michael G.; Smaranda, Nicole C.; Steves, Patrick L.
- Abstract
Aim: To assess plasma zinc and copper concentration in individuals with autism and correlate these levels with symptom severity. Subjects and methods: Plasma from 102 autistic individuals, and 18 neurotypical controls, were tested for plasma zinc and copper using inductively-coupled plasma-mass spectrometry. Copper and zinc levels and Cu/Zn were analyzed for possible correlation with severity of 19 symptoms. Results: Autistic individuals had elevated plasma levels of copper and Cu/Zn and lower, but not significantly lower, plasma Zn compared to neurotypical controls. There was a correlation between Cu/Zn and expressive language, receptive language, focus attention, hyperactivity, fine motor skills, gross motor skills and Tip Toeing. There was a negative correlation between plasma zinc concentration and hyperactivity, and fine motor skills severity. Discussion: These results suggest an association between plasma Cu/Zn and severity of symptoms associated with autism.
- Subjects
COPPER research; ZINC; AUTISM research; INDUCTIVELY coupled plasma mass spectrometry; MASS spectrometry
- Publication
Nutrition & Metabolic Insights, 2012, Issue 5, p41
- ISSN
1178-6388
- Publication type
Article
- DOI
10.4137/NMI.S8761