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- Title
Viral miRNAs as Active Players and Participants in Tumorigenesis.
- Authors
Gallo, Alessia; Miceli, Vitale; Bulati, Matteo; Iannolo, Gioacchin; Contino, Flavia; Conaldi, Pier Giulio
- Abstract
The theory that viruses play a role in human cancers is now supported by scientific evidence. In fact, around 12% of human cancers, a leading cause of morbidity and mortality in some regions, are attributed to viral infections. However, the molecular mechanism remains complex to decipher. In recent decades, the uncovering of cellular miRNAs, with their invaluable potential as diagnostic and prognostic biomarkers, has increased the number of studies being conducted regarding human cancer diagnosis. Viruses develop clever mechanisms to succeed in the maintenance of the viral life cycle, and some viruses, especially herpesviruses, encode for miRNA, v-miRNAs. Through this viral miRNA, the viruses are able to manipulate cellular and viral gene expression, driving carcinogenesis and escaping the host innate or adaptive immune system. In this review, we have discussed the main viral miRNAs and virally influenced cellular pathways, and their capability to drive carcinogenesis.
- Subjects
CARCINOGENESIS; BIOMARKERS; GENE expression; HEPATITIS viruses; IMMUNE system; PAPILLOMAVIRUSES; VIRUS diseases; MICRORNA
- Publication
Cancers, 2020, Vol 12, Issue 2, p358
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers12020358