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- Title
The Role of Apoptosis in the Pathology of Pancreatic Cancer.
- Authors
Samm, Nicole; Werner, Kristin; Rückert, Felix; Saeger, Hans Detlev; Grützmann, Robert; Pilarsky, Christian
- Abstract
Pancreatic cancer is a disease with high resistance to most common therapies and therefore has a poor prognosis, which is partly due to a lack of reaction to apoptotic stimuli. Signal transduction of such stimuli includes a death receptor-mediated extrinsic pathway as well as an intrinsic pathway linked to the mitochondria. Defects in apoptotic pathways and the deregulation of apoptotic proteins, such as Survivin, Bcl-2, Bcl-xL and Mcl-1, play decisive roles in the development of pancreatic cancer. Investigation of the molecular mechanism allowing tumors to resist apoptotic cell death would lead to an improved understanding of the physiology and the development of new molecular strategies in pancreatic cancer.
- Subjects
APOPTOSIS; PANCREATIC cancer; THERAPEUTICS; PROGNOSIS; MITOCHONDRIA; CELLULAR signal transduction; CELL death; PHYSIOLOGY; MOLECULAR carcinogenesis
- Publication
Cancers, 2011, Vol 3, Issue 1, p1
- ISSN
2072-6694
- Publication type
Article
- DOI
10.3390/cancers3010001