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- Title
Histopathological Study for Experimentally Induced Malassezia Causing Pityriasis Versicolor in Laboratory White Rats (Rattus Norvegicus).
- Authors
Al-Hamdani, Farqad M.; Almallak, Maha K. I.; AlSaimary, Ihsan E.; Al Hamdi, Khalil I.; Muhammad, Muslim A.
- Abstract
The study aimed to evaluate histopathological changes associated with pityriasis versicolor by animal models experimentally injected with Malassezia species spores isolatd from patients of Basra province and variable injecting pathways(intradermally, spotted and scratching injection)was applied. Histopathological findings of skin specimens related to the infected rats with Malassezia furfur by intradermally method showed sever infiltration of inflammatory cells on superficial layer, the epidermis with moderate hyperkeratosis while the dermis appeared as dense connective tissue with large amount of irregular collagenous fibers interspersed with fibroblasts and variable number of hair follicles with associated sebaceous glands. Recent findings referred to sever histological alterations in skin sections related to infected rats with Malassezia species by scratching method, include activated keratinocytes, destruction of epidermal barrier, heavy proliferation of keratinocytes, no dermal papillae observed, the infection was specific for keratin layers, but inflammation extend to dermis and subcutaneous layers through invasion the hair follicles. Sections from shoulder and back of infected rats showed destruction and maceration of epidermis start from stratum corneum, spinosum showed proliferation and acanthosis. Moreover, results revealed to the M.furfur as lipophilic yeast colonized around the sebaceous glands, the destruction and atrophied sebaceous glands associated with changes in hair follicles diameter
- Subjects
RATTUS norvegicus; LABORATORY rats; MALASSEZIA; EPIDERMIS; SEBACEOUS glands; HAIR follicles; CONNECTIVE tissues
- Publication
Indian Journal of Forensic Medicine & Toxicology, 2019, Vol 13, Issue 3, p319
- ISSN
0973-9122
- Publication type
Article
- DOI
10.5958/0973-9130.2019.00216.0