We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Amperozide Influences Feeding Independently of 5-HT[sub 2A] Receptor Antagonism.
- Authors
Price, Ingrid V.; Gorzalka, Boris B.; White, Sarah J.; Arkinstall, Kim H.
- Abstract
Amperozide has been biochemically classified as a selective 5-HT[sub 2A] (serotonin type 2A) receptor antagonist. However, research on the behavioral effects of amperozide suggests the possibility of other mechanisms. The present study in the male rat is an investigation of the effect of amperozide on feeding, a behavior which can be inhibited by 5-HT[sub 2A] agonists such as 1-(2,5-dimethoxy-4-iodophenyl)-2-aminopropane (DOI). Experiments revealed that amperozide acted to inhibit feeding behavior both when administered alone and when administered in combination with DOI. These results are inconsistent with 5-HT[sub 2A] receptor antagonism by amperozide. Further experiments suggested that amperozide may be acting via α[sub 2] -adrenergic or 5-HT[sub 1A] receptors to inhibit feeding. These studies imply that amperozide’s selective 5-HT[sub 2A] antagonistic activity is behaviorally specific.
- Subjects
SEROTONIN antagonists; ANIMAL feeding; CHEMICALS; ADRENERGIC receptors
- Publication
Neuropsychobiology, 1998, Vol 37, Issue 3, p155
- ISSN
0302-282X
- Publication type
Article
- DOI
10.1159/000026495