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- Title
Rebound in Measures of Disease Activity and Symptoms in Corrona Registry Patients with Psoriatic Arthritis Who Discontinue Tumor Necrosis Factor Inhibitor Therapy after Achieving Low Disease Activity.
- Authors
Harrold, Leslie R.; Stolshek, Bradley S.; Rebello, Sabrina; Collier, David H.; Mutebi, Alex; Wade, Sally W.; Malley, Wendi; Greenberg, Jeffrey D.; Etzel, Carol J.
- Abstract
<bold>Objective: </bold>Rebound may occur in patients with psoriatic arthritis (PsA) who discontinue TNF inhibitor (TNFi) therapy in low disease activity (LDA).<bold>Methods: </bold>Using physician and patient reports, we quantified rebound following TNFi discontinuation [defined as Clinical Disease Activity Index (CDAI) score > 10 or TNFi restart] and time to rebound in adults with PsA in LDA (CDAI score ≤ 10) at TNFi discontinuation.<bold>Results: </bold>Rebound occurred in 73% (69/94) of patients soon after discontinuation (median time to rebound 8.0 mos, 95% CI 6.0-12.0).<bold>Conclusion: </bold>Rebound occurred frequently in patients with PsA after TNFi discontinuation. TNFi discontinuation after achieving LDA should be carefully considered.
- Publication
Journal of Rheumatology, 2018, Vol 45, Issue 1, p78
- ISSN
0315-162X
- Publication type
journal article
- DOI
10.3899/jrheum.161567