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- Title
Simultaneous expression of COX-2 and mPGES-1 in mouse gastrointestinal hamartomas.
- Authors
Takeda, H.; Miyoshi, H.; Tamai, Y.; Oshima, M.; Taketo, M. M.
- Abstract
Cyclo-oxygenase (COX)-2 is induced in various types of cancer tissues. Here, we demonstrate stromal expression of both COX-2 and microsomal prostaglandin E2 synthase (mPGES)-1 in gastrointestinal hamartomas developed in Lkb1+/-, Smad4+/- and Cdx2+/-mice. These results suggest that PGE2 produced by COX-2 and mPGES-1 plays an important role in hamartoma development regardless of the mutated genes causing hamartomas.British Journal of Cancer (2004) 90, 701-704. doi:10.1038/sj.bjc.6601584 www.bjcancer.com
- Subjects
OXYGENASES; GASTROINTESTINAL cancer; LABORATORY mice; PROSTAGLANDINS E; GENETIC mutation; OXIDOREDUCTASES
- Publication
British Journal of Cancer, 2004, Vol 90, Issue 3, p701
- ISSN
0007-0920
- Publication type
Article
- DOI
10.1038/sj.bjc.6601584