We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Early-life house dust mite allergens, childhood mite sensitization, and respiratory outcomes.
- Authors
Casas, L.; Sunyer, J.; Tischer, C.; Gehring, U.; Wickman, M.; Garcia‐Esteban, R.; Lehmann, I.; Kull, I.; Reich, A.; Lau, S.; Wijga, A.; Antó, J. M.; Nawrot, T. S.; Heinrich, J.; Keil, T.; Torrent, M.
- Abstract
Background Exposure to indoor allergens during early life may play a role in the development of the immune system and inception of asthma. Objective To describe the house dust mite ( HDM) allergen concentrations in bedroom dust during early life and to evaluate its associations with HDM sensitization, wheezing, and asthma, from birth to school age, in 5 geographically spread European birth cohorts. Methods We included 4334 children from INMA- Menorca ( Spain), BAMSE ( Sweden), LISAplus and MAS ( Germany), and PIAMA- NHS (the Netherlands). Dust samples were collected from bedrooms during early life and analyzed for Dermatophagoides pteronyssinus ( Der p1) and Dermatophagoides farinae ( Der f1). HDM concentrations were divided into four categories. Sensitization was determined by specific Ig E. Wheezing and asthma information up to 8/10 years was collected through questionnaires. We performed mixed-effects logistic regression models and expressed associations as odds ratios with 95% confidence intervals. Results House dust mite concentrations varied across cohorts. Mean allergen concentrations were highest in INMA-Menorca (geometric mean ( GM) Der p1 = 3.3 μg/g) and LISAplus ( GM Der f1 = 2.1 μg/g) and lowest in BAMSE ( GM Der p1 = 0.1 μg/g, Der f1 = 0.3 μg/g). Moderate and high HDM concentrations were significantly ( P-values < 0.05) associated with 50-90% higher prevalence of HDM sensitization. No significant associations were observed with respiratory outcomes. Conclusion Our study based on geographically spread regions, a large sample size, and a wide range of allergen concentration shows that HDM allergen concentrations vary across regions and that exposure during early life plays a role in the development of allergic sensitization but not in the development of respiratory outcomes.
- Subjects
HOUSE dust mites; ALLERGENS; RESPIRATION; ALLERGY in children; SENSITIZATION (Neuropsychology)
- Publication
Allergy, 2015, Vol 70, Issue 7, p820
- ISSN
0105-4538
- Publication type
Article
- DOI
10.1111/all.12626