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- Title
Neurocognitive and behavioural profile in Panayiotopoulos syndrome.
- Authors
Fonseca Wald, Eric L A; Debeij‐Van Hall, Mariette H J A; De Jong, Eline; Aldenkamp, Albert P; Vermeulen, R Jeroen; Vles, Johan S H; Klinkenberg, Sylvia; Hendriksen, Jos G M; Debeij-Van Hall, Mariette H J A
- Abstract
<bold>Aim: </bold>To determine neurocognitive performance and behavioural problems in children with Panayiotopoulos syndrome.<bold>Method: </bold>All 18 children (10 females, 8 males; mean age 4y 7mo; SD 1y 10mo) diagnosed with Panayiotopoulos syndrome at the Kempenhaeghe Epilepsy Center in the Netherlands between 2010 and 2017 were analysed retrospectively. All underwent a neuropsychological/behavioural assessment, an academic assessment, and a 24-hour electroencephalogram.<bold>Results: </bold>Mean full-scale IQ (93.5; range 76-123; p=0.04) and performance IQ (93.2; range 76-126; p=0.04) were within the normal range, although significantly lower compared to the normative mean. Verbal IQ (96.3; range 76-118) and processing speed (96.1; range 74-114) were not significantly lower. Simple auditory/visual reaction times, visual attention, visual-motor integration, and verbal memory were significantly lower compared to normative values. On average, patients with Panayiotopoulos syndrome were 8 months behind in arithmetic speed and 11 months behind in reading speed for the number of months in school. Behavioural questionnaires revealed significantly higher scores on reported internalizing behavioural problems.<bold>Interpretation: </bold>Children with Panayiotopoulos syndrome demonstrated diffuse cognitive dysfunction in full-scale IQ, performance IQ, visual attention, visual-motor integration, and verbal memory. A high incidence of internalizing behavioural problems was reported. This strongly suggests neuropsychological and behavioural comorbidity in children with Panayiotopoulos syndrome.<bold>What This Paper Adds: </bold>Children with Panayiotopoulos syndrome are at risk for cognitive deficits in various cognitive domains. Children with Panayiotopoulos syndrome are also prone to internalizing behavioural problems. Mild-to-severe academic underachievement was present in more than half of the children with Panayiotopoulos syndrome.
- Subjects
NETHERLANDS; VERBAL memory; ACADEMIC underachievement; MENTAL arithmetic; SYNDROMES; EPILEPSY &; psychology; COGNITION disorders; RESEARCH; EPILEPSY; RESEARCH methodology; RETROSPECTIVE studies; EVALUATION research; MEDICAL cooperation; NEUROPSYCHOLOGICAL tests; COMPARATIVE studies; RESEARCH funding; EDUCATIONAL attainment; PSYCHOLOGICAL factors; DISEASE complications
- Publication
Developmental Medicine & Child Neurology, 2020, Vol 62, Issue 8, p985
- ISSN
0012-1622
- Publication type
journal article
- DOI
10.1111/dmcn.14417