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- Title
Changes in posterior corneal elevations after combined transepithelial photorefractive keratectomy and accelerated corneal collagen cross-linking: retrospective, comparative observational case series.
- Authors
Hun Lee; David Sung Yong Kang; Byoung Jin Ha; Jin Young Choi; Eung Kweon Kim; Kyoung Yul Seo; Tae-im Kim; Lee, Hun; Kang, David Sung Yong; Ha, Byoung Jin; Choi, Jin Young; Kim, Eung Kweon; Seo, Kyoung Yul; Kim, Tae-Im
- Abstract
<bold>Background: </bold>To compare the changes in anterior and posterior corneal elevations after combined transepithelial photorefractive keratectomy (PRK) and accelerated corneal collagen cross-linking (CXL) and after PRK.<bold>Methods: </bold>Medical records of 82 eyes of 44 patients undergoing either combined transepithelial PRK and CXL (PRK-CXL group) or transepithelial PRK (PRK group) were examined retrospectively. Changes in anterior and posterior corneal elevations were calculated by fitting an 8.0-mm diameter best-fit sphere and best-fit toric ellipsoid (BFTE) to the corneal shape with a fixed eccentricity of 0.4 using Scheimpflug tomography (Pentacam HR; Oculus Optikgeräte GmbH, Wetzlar, Germany) preoperatively and 6 months postoperatively.<bold>Results: </bold>In anterior corneal elevation, both groups demonstrated a similar trend of a forward displacement of peripheral anterior corneal surface and a backward displacement of central anterior corneal surface. In posterior corneal elevation, a forward displacement of peripheral posterior corneal surface was induced in both groups, along with a backward displacement of central posterior corneal surface, regardless of the calculation method. The magnitudes of displacement of peripheral and central posterior corneal surfaces were significantly smaller in the PRK-CXL group than in the PRK group. Moreover, the PRK-CXL group showed a backward displacement of posterior corneal surface at maximum corneal elevations when the BFTE was used as the reference surface.<bold>Conclusions: </bold>Transepithelial PRK combined with prophylactic CXL significantly reduced the magnitudes of displacement of peripheral and central posterior corneal surfaces, with the radius of the BFTE was set to 8.0-mm on the Scheimpflug tomography system.
- Subjects
PHOTOREFRACTIVE keratectomy; PROTEIN crosslinking; CORNEAL topography; COLLAGEN; RETROSPECTIVE studies; PHOTOSENSITIZERS; EPITHELIUM; CHEMICAL reagents; COMBINED modality therapy; COMPARATIVE studies; COMPUTED tomography; CORNEA; RESEARCH methodology; MEDICAL cooperation; MYOPIA; PHOTOCHEMOTHERAPY; RESEARCH; SURGICAL complications; EVALUATION research; METABOLISM; SURGERY; THERAPEUTICS
- Publication
BMC Ophthalmology, 2016, Vol 16, p1
- ISSN
1471-2415
- Publication type
journal article
- DOI
10.1186/s12886-016-0320-3