We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Potential of Directed Cord Blood Donations for the Treatment of Patients with Hematologic Disorders.
- Authors
Brune, Thomas; Garritsen, Henk S. P.
- Abstract
Directed cord blood donations are donations in which a family that has a child or other family member with a malignant or nonmalignant disease that is potentially treatable with stem cell transplantation, banks cord blood in subsequent pregnancies for future transplantation. With the present study we evaluate the effectiveness of directed cord blood donations. Patients and Methods: Within a 3-year period we analyzed directed cord blood collections in 27 families in which a family member had a malignant (primary hematological) disease. Results: The amount of collected cord blood was 75 ml median (20-168 ml). The amount of CD34+ cells per collection varied from 0.13 × 106 to 30.9 × 10 6 (median 5.1 × 10 6). Screening for bacterial contamination was negative in all collections. HLA typing of the collected cord blood showed HLA identity to the patient in 8 (25%) of the 32 cord blood collections. In 2 cases (6.25%) 1 HLA mismatch was found and in 10 cases (31.25%) 2 HLA mismatches. The other 12 (37.5%) collected cord blood samples displayed at least 3 HLA mismatches. Assuming 2 HLA mismatches as a cut-off for acceptance would mean that 62.5% of the patients in the investigated group would have an HLA-compatible directed cord blood donation. Conclusions: Our investigation showed that directed cord blood banking is a potential option in families with a family member which has a disorder potentially treatable with stem cell transplantation.
- Subjects
CORD blood; HEMATOPOIETIC stem cells; LEUKEMIA; STEM cell transplantation; ORGAN donation
- Publication
Transfusion Medicine & Hemotherapy, 2007, Vol 34, Issue 2, p100
- ISSN
1660-3796
- Publication type
Article
- DOI
10.1159/000100424