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- Title
Cell-surface H<sup>+</sup>-ATP synthase as a potential molecular target for anti-obesity drugs
- Authors
Arakaki, Naokatu; Kita, Toshiyuki; Shibata, Hirofumi; Higuti, Tomihiko
- Abstract
Abstract: Here we show that the cell-surface expression of the alpha subunit of H+-ATP synthase is markedly increased during adipocyte differentiation. Treatment of differentiated adipocytes with small molecule inhibitors of H+-ATP synthase or antibodies against alpha and beta subunits of H+-ATP synthase leads to a decrease in cytosolic lipid droplet accumulation. Apolipoprotein A-I, which has been shown to bind to the ectopic β-chain of H+-ATP synthase and inhibit the activity of cell-surface H+-ATP synthase, also was found to inhibit cytosolic lipid accumulation. These results suggest that the cell-surface H+-ATP synthase has a previously unsuspected role in lipid metabolism in adipocytes.
- Subjects
OBESITY; ADENOSINE triphosphatase; IMMUNOGLOBULINS; METABOLISM
- Publication
FEBS Letters, 2007, Vol 581, Issue 18, p3405
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2007.06.041