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- Title
Distinct mechanisms underlie distinct polyphenol-induced neuroprotection
- Authors
Yazawa, Keiko; Kihara, Takeshi; Shen, Huilian; Shimmyo, Yoshiari; Niidome, Tetsuhiro; Sugimoto, Hachiro
- Abstract
Abstract: Glutamate excitotoxicity is mediated by intracellular Ca2+ overload, caspase-3 activation, and ROS generation. Here, we show that curcumin, tannic acid (TA) and (+)-catechin hydrate (CA) all inhibited glutamate-induced excitotoxicity. Curcumin inhibited PKC activity, and subsequent phosphorylation of NR1 of the NMDA receptor. As a result, glutamate-mediated Ca2+ influx was reduced. TA attenuated glutamate-mediated Ca2+ influx only when simultaneously administered, directly interfering with Ca2+. Both curcumin and TA inhibited glutamate-induced caspase-3 activation. Although Ca2+ influx was not attenuated by CA, caspase-3 was reduced by direct inhibition of the enzyme. All polyphenols reduced glutamate-induced generation of ROS.
- Subjects
PROTEIN kinases; POLYPHENOLS; REACTIVE oxygen species; PROTEIN kinase C
- Publication
FEBS Letters, 2006, Vol 580, Issue 28/29, p6623
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2006.11.011