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- Title
A novel 4.1 ezrin radixin moesin (FERM)-containing protein, ‘Willin’
- Authors
Gunn-Moore, Frank J.; Welsh, Gavin I.; Herron, Lissa R.; Brannigan, Frances; Venkateswarlu, Kanamarlapudi; Gillespie, Stewart; Brandwein-Gensler, Margaret; Madan, Rashna; Tavaré, Jeremy M.; Brophy, Peter J.; Prystowsky, Michael B.; Guild, Simon
- Abstract
Abstract: The 4.1 superfamily of proteins contain a 4.1 Ezrin Radixin Moesin (FERM) domain and are described as linking the cytoskeleton with the plasma membrane. Here, we describe a new FERM domain-containing protein called Willin. Willin has a recognizable FERM domain within its N-terminus and is capable of binding phospholipids. Its intra-cellular distribution can be cytoplasmic or at the plasma membrane where it can co-localize with actin. However, the plasma membrane location of Willin is not influenced by cytochalasin D induced actin disruption but it is induced by the addition of epidermal growth factor.
- Subjects
CELL membranes; ACTIN; GROWTH factors; EPIDERMAL growth factor; CYTOKINES
- Publication
FEBS Letters, 2005, Vol 579, Issue 22, p5089
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/j.febslet.2005.07.097