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- Title
Insights into the structure of human cytomegalovirus large terminase subunit pUL56
- Authors
Savva, Christos G.W.; Holzenburg, Andreas; Bogner, Elke
- Abstract
Terminases are a class of proteins which catalyze the generation of unit-length genomes during DNA packaging. These essential proteins are conserved throughout the herpesviruses and many double-stranded DNA bacteriophages. We have determined the structure of the large terminase subunit pUL56 of human cytomegalovirus, a highly pathogenic virus, to 2.6 nm resolution. Image analysis of purified pUL56 suggests that the molecule exists as a dimer formed by the association of two ring-like structures positioned on top of each other and connected by a pronounced density on one side. The 3D reconstruction of pUL56 provides first structural insights into the active protein.
- Subjects
PROTEINS; GENES; GENOMES; IMAGING systems
- Publication
FEBS Letters, 2004, Vol 563, Issue 1-3, p135
- ISSN
0014-5793
- Publication type
Article
- DOI
10.1016/S0014-5793(04)00283-2