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- Title
Effects of Passiflora cincinnata in murine models of nociception.
- Authors
do Nascimento Sales, Emmily Petícia; Cabral, Francisco Romero; dos Santos Sales, Valterlúcio; de Lacerda, Josefa Fernanda Evangelista; da Silva, Luanna Gomes; Correia, Denise Bezerra; de Araújo Delmondes, Gyllyandeson; Lima, Cícera Norma Fernandes; Monteiro, Álefe Brito; Felipe, Cícero Francisco Bezerra; dos Santos, Francisco Antonio Vieira; Ribeiro-Filho, Jaime; de Menezes, Irwin Rose Alencar; Coutinho, Henrique Douglas Melo; Kerntopf, Marta Regina
- Abstract
The present study aimed to characterize the chemical composition and investigate the antinociceptive effects of the hydroalcoholic extract of Passiflora cincinnata leaves (HEPCL) in different animal models of nociception. High-performance liquid chromatography (HPLC) analysis revealed the presence of compounds such as orientin, rutin, vitexin, quercetin, apigenin, epicatechin, catechin, and gallic acid in the chemical of the chemical composition of the extract. The oral administration of HEPCL induced significant analgesia in different nociception models, including acetic acid-induced abdominal contortions, licking response induced by formalin, capsaicin, and glutamate, hot-plate test, tail-flick test, and mechanical nociception, which suggests that the extract components might act through multiple antinociceptive mechanisms.
- Subjects
ORAL drug administration; HIGH performance liquid chromatography; GALLIC acid; PASSIFLORA; EPICATECHIN; ACETIC acid
- Publication
Biologia, 2024, Vol 79, Issue 1, p161
- ISSN
0006-3088
- Publication type
Article
- DOI
10.1007/s11756-023-01516-1