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Nebulin: big protein with big responsibilities.
Published in:
Journal of Muscle Research & Cell Motility, 2020, v. 41, n. 1, p. 103, doi. 10.1007/s10974-019-09565-3
By:
- Yuen, Michaela;
- Ottenheijm, Coen A. C.
Publication type:
Article
Diaphragm Pathology in Critically Ill Patients With COVID-19 and Postmortem Findings From 3 Medical Centers.
Published in:
2021
By:
- Shi, Zhonghua;
- de Vries, Heder J.;
- Vlaar, Alexander P. J.;
- van der Hoeven, Johannes;
- Boon, Reinier A.;
- Heunks, Leo M. A.;
- Ottenheijm, Coen A. C.;
- Dutch COVID-19 Diaphragm Investigators
Publication type:
journal article
Deleting Titin's C-Terminal PEVK Exons Increases Passive Stiffness, Alters Splicing, and Induces Cross-Sectional and Longitudinal Hypertrophy in Skeletal Muscle.
Published in:
Frontiers in Physiology, 2020, v. 11, p. 1, doi. 10.3389/fphys.2020.00494
By:
- van der Pijl, Robbert J.;
- Hudson, Brian;
- Granzier-Nakajima, Tomotaroh;
- Li, Frank;
- Knottnerus, Anne M.;
- Smith, John;
- Chung, Charles S.;
- Gotthardt, Michael;
- Granzier, Henk L.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Rbm20 ΔRRM Mice, Expressing a Titin Isoform with Lower Stiffness, Are Protected from Mechanical Ventilation-Induced Diaphragm Weakness.
Published in:
International Journal of Molecular Sciences, 2022, v. 23, n. 24, p. 15689, doi. 10.3390/ijms232415689
By:
- van den Berg, Marloes;
- Peters, Eva L.;
- van der Pijl, Robbert J.;
- Shen, Shengyi;
- Heunks, Leo M. A.;
- Granzier, Henk L.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Troponin Variants in Congenital Myopathies: How They Affect Skeletal Muscle Mechanics.
Published in:
International Journal of Molecular Sciences, 2021, v. 22, n. 17, p. 9187, doi. 10.3390/ijms22179187
By:
- van de Locht, Martijn;
- Borsboom, Tamara C.;
- Winter, Josine M.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Effect of levosimendan on the contractility of muscle fibers from nemaline myopathy patients with mutations in the nebulin gene.
Published in:
Skeletal Muscle, 2015, v. 5, n. 1, p. 1, doi. 10.1186/s13395-015-0037-7
By:
- de Winter, Josine M.;
- Joureau, Barbara;
- Sequeira, Vasco;
- Clarke, Nigel F.;
- van der Velden, Jolanda;
- Stienen, Ger J. M.;
- Granzier, Henk;
- Beggs, Alan H.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Association of diaphragm thickness and echogenicity with age, sex, and body mass index in healthy subjects.
Published in:
Muscle & Nerve, 2022, v. 66, n. 2, p. 197, doi. 10.1002/mus.27639
By:
- van Doorn, Jeroen L. M.;
- Wijntjes, Juerd;
- Saris, Christiaan G. J.;
- Ottenheijm, Coen A. C.;
- van Alfen, Nens;
- Doorduin, Jonne
Publication type:
Article
Replacement Fibrosis in the Diaphragm of Mechanically Ventilated Critically Ill Patients.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2023, v. 207, n. 3, p. 351, doi. 10.1164/rccm.202208-1608LE
By:
- Zhonghua Shi;
- van den Berg, Marloes;
- Beishuizen, Albertus;
- Heunks, Leo;
- Ottenheijm, Coen A. C.
Publication type:
Article
Positive End-Expiratory Pressure Ventilation Induces Longitudinal Atrophy in Diaphragm Fibers.
Published in:
2018
By:
- Lindqvist, Johan;
- van den Berg, Marloes;
- van der Pijl, Robbert;
- Hooijman, Pleuni E;
- Beishuizen, Albertus;
- Elshof, Judith;
- de Waard, Monique;
- Girbes, Armand;
- Spoelstra-de Man, Angelique;
- Shi, Zhong-Hua;
- van den Brom, Charissa;
- Bogaards, Sylvia;
- Shen, Shengyi;
- Strom, Joshua;
- Granzier, Henk;
- Kole, Jeroen;
- Musters, René J P;
- Paul, Marinus A;
- Heunks, Leo M A;
- Ottenheijm, Coen A C
Publication type:
journal article
Diaphragm Atrophy and Weakness in the Absence of Mitochondrial Dysfunction in the Critically Ill.
Published in:
2017
By:
- van den Berg, Marloes;
- Hooijman, Pleuni E.;
- Beishuizen, Albertus;
- de Waard, Monique C.;
- Paul, Marinus A.;
- Hartemink, Koen J.;
- van Hees, Hieronymus W. H.;
- Lawlor, Michael W.;
- Brocca, Lorenza;
- Bottinelli, Roberto;
- Pellegrino, Maria A.;
- Stienen, Ger J. M.;
- Heunks, Leo M. A.;
- Wüst, Rob C. I.;
- Ottenheijm, Coen A. C.
Publication type:
journal article
Diaphragm muscle fiber weakness and ubiquitin-proteasome activation in critically ill patients.
Published in:
2015
By:
- Hooijman, Pleuni E;
- Beishuizen, Albertus;
- Witt, Christian C;
- de Waard, Monique C;
- Girbes, Armand R J;
- Spoelstra-de Man, Angelique M E;
- Niessen, Hans W M;
- Manders, Emmy;
- van Hees, Hieronymus W H;
- van den Brom, Charissa E;
- Silderhuis, Vera;
- Lawlor, Michael W;
- Labeit, Siegfried;
- Stienen, Ger J M;
- Hartemink, Koen J;
- Paul, Marinus A;
- Heunks, Leo M A;
- Ottenheijm, Coen A C
Publication type:
journal article
Diaphragm Muscle Fiber Weakness and Ubiquitin–Proteasome Activation in Critically Ill Patients.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. 1126, doi. 10.1164/rccm.201412-2214OC
By:
- Hooijman, Pleuni E.;
- Beishuizen, Albertus;
- Witt, Christian C.;
- de Waard, Monique C.;
- Girbes, Armand R. J.;
- Spoelstra-de Man, Angelique M. E.;
- Niessen, Hans W. M.;
- Manders, Emmy;
- van Hees, Hieronymus W. H.;
- van den Brom, Charissa E.;
- Silderhuis, Vera;
- Lawlor, Michael W.;
- Labeit, Siegfried;
- Stienen, Ger J. M.;
- Hartemink, Koen J.;
- Paul, Marinus A.;
- Heunks, Leo M. A.;
- Ottenheijm, Coen A. C.
Publication type:
Article
DIAPHRAGM MUSCLE FIBER WEAKNESS AND UBIQUITIN-PROTEASOME ACTIVATION IN CRITICALLY ILL PATIENTS.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2015, v. 191, n. 10, p. E1, doi. 10.1164/rccm.201412-2214oc
By:
- Hooijman, Pleuni E.;
- Beishuizen, Albertus;
- Witt, Christian C.;
- de Waard, Monique C.;
- Girbes, Armand R. J.;
- Spoelstra-de Man, Angelique M. E.;
- Niessen, Hans W. M.;
- Manders, E.;
- van Hees, Hieronymus W. H.;
- van den Brom, Charissa E.;
- Silderhuis, Vera;
- Lawlor, Michael W.;
- Labeit, Siegfried;
- Stienen, Ger J. M.;
- Hartemink, Koen J.;
- Paul, Marinus A.;
- Heunks, Leo M. A.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Diaphragm adaptations in patients with COPD.
Published in:
Respiratory Research, 2008, v. 9, p. 1, doi. 10.1186/1465-9921-9-12
By:
- Ottenheijm, Coen A. C.;
- Heunks, Leo M. A.;
- Dekhuijzen, Richard P. N.
Publication type:
Article
Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.
Published in:
BMC Neurology, 2013, v. 13, n. 1, p. 1, doi. 10.1186/1471-2377-13-144
By:
- Lassche, Saskia;
- Ottenheijm, Coen A. C.;
- Voermans, Nicol C.;
- Westeneng, Henk-Jan;
- Janssen, Barbara H.;
- van der Maarel, Silvère M.;
- Hopman, Maria T.;
- Padberg, George W.;
- Stienen, Ger J. M.;
- van Engelen, Baziel G. M.
Publication type:
Article
Determining the role of sarcomeric proteins in facioscapulohumeral muscular dystrophy: a study protocol.
Published in:
2013
By:
- Lassche, Saskia;
- Ottenheijm, Coen Ac;
- Voermans, Nicol C;
- Westeneng, Henk-Jan;
- Janssen, Barbara H;
- van der Maarel, Silvère M;
- Hopman, Maria T;
- Padberg, George W;
- Stienen, Ger Jm;
- van Engelen, Baziel Gm;
- Ottenheijm, Coen A C;
- Stienen, Ger J M;
- van Engelen, Baziel G M
Publication type:
journal article
Nebulin nemaline myopathy recapitulated in a compound heterozygous mouse model with both a missense and a nonsense mutation in Neb.
Published in:
Acta Neuropathologica Communications, 2020, v. 8, n. 1, p. 1, doi. 10.1186/s40478-020-0893-1
By:
- Laitila, Jenni M.;
- McNamara, Elyshia L.;
- Wingate, Catherine D.;
- Goullee, Hayley;
- Ross, Jacob A.;
- Taylor, Rhonda L.;
- van der Pijl, Robbert;
- Griffiths, Lisa M.;
- Harries, Rachel;
- Ravenscroft, Gianina;
- Clayton, Joshua S.;
- Sewry, Caroline;
- Lawlor, Michael W.;
- Ottenheijm, Coen A. C.;
- Bakker, Anthony J.;
- Ochala, Julien;
- Laing, Nigel G.;
- Wallgren-Pettersson, Carina;
- Pelin, Katarina;
- Nowak, Kristen J.
Publication type:
Article
Deleting exon 55 from the nebulin gene induces severe muscle weakness in a mouse model for nemaline myopathy.
Published in:
Brain: A Journal of Neurology, 2013, v. 136, n. 6, p. 1718, doi. 10.1093/brain/awt113
By:
- Ottenheijm, Coen A. C.;
- Buck, Danielle;
- de Winter, Josine M.;
- Ferrara, Claudia;
- Piroddi, Nicoletta;
- Tesi, Chiara;
- Jasper, Jeffrey R.;
- Malik, Fady I.;
- Meng, Hui;
- Stienen, Ger J. M.;
- Beggs, Alan H.;
- Labeit, Siegfried;
- Poggesi, Corrado;
- Lawlor, Michael W.;
- Granzier, Henk
Publication type:
Article
Nebulin, a major player in muscle health and disease.
Published in:
FASEB Journal, 2011, v. 25, n. 3, p. 822, doi. 10.1096/fj.10-157412
By:
- Labeit, Siegfried;
- Ottenheijm, Coen A. C.;
- Granzier, Henk
Publication type:
Article
Comprehensive phenotypic characterization of an allelic series of zebrafish models of NEB-related nemaline myopathy.
Published in:
Human Molecular Genetics, 2024, v. 33, n. 12, p. 1036, doi. 10.1093/hmg/ddae033
By:
- Fabian, Lacramioara;
- Karimi, Esmat;
- Farman, Gerrie P;
- Gohlke, Jochen;
- Ottenheijm, Coen A C;
- Granzier, Hendrikus L;
- Dowling, James J
Publication type:
Article
Dysfunctional sarcomere contractility contributes to muscle weakness in ACTA1-related nemaline myopathy (NEM3).
Published in:
2018
By:
- Joureau, Barbara;
- de Winter, Josine Marieke;
- Conijn, Stefan;
- Bogaards, Sylvia J. P.;
- Kovacevic, Igor;
- Kalganov, Albert;
- Persson, Malin;
- Lindqvist, Johan;
- Stienen, Ger J. M.;
- Irving, Thomas C.;
- Ma, Weikang;
- Yuen, Michaela;
- Clarke, Nigel F.;
- Rassier, Dilson E.;
- Malfatti, Edoardo;
- Romero, Norma B.;
- Beggs, Alan H.;
- Ottenheijm, Coen A. C.
Publication type:
journal article
Sarcoplasmic reticulum calcium uptake and speed of relaxation are depressed in nebulin-free skeletal muscle.
Published in:
FASEB Journal, 2008, v. 22, n. 8, p. 2912, doi. 10.1096/fj.07-104372
By:
- Ottenheijm, Coen A. C.;
- Chi Fong;
- Vangheluwe, Peter;
- Wuytack, Frank;
- Babu, Gopal J.;
- Periasamy, Muthu;
- Witt, Christian C.;
- Labeit, Siegfried;
- Granzier, Henk
Publication type:
Article
Diaphragm fiber strength is reduced in critically ill patients and restored by a troponin activator.
Published in:
2014
By:
- Hooijman, Pleuni E;
- Beishuizen, Albertus;
- de Waard, Monique C;
- de Man, Frances S;
- Vermeijden, J W;
- Steenvoorde, Pascal;
- Bouwman, R Arthur;
- Lommen, Wies;
- van Hees, Hieronymus W H;
- Heunks, Leo M A;
- Dickhoff, Chris;
- van der Peet, Donald L;
- Girbes, Armand R J;
- Jasper, Jeff R;
- Malik, Fady I;
- Stienen, Ger J M;
- Hartemink, Koen J;
- Paul, Marinus A;
- Ottenheijm, Coen A C
Publication type:
Letter
Diaphragm Fiber Strength Is Reduced in Critically Ill Patients and Restored by a Troponin Activator.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2014, v. 189, n. 7, p. 863, doi. 10.1164/rccm.201312-2260le
By:
- Hooijman, Pleuni E.;
- Beishuizen, Albertus;
- de Waard, Monique C.;
- de Man, Frances S.;
- Vermeijden, J. W.;
- Steenvoorde, Pascal;
- Arthur Bouwman, R.;
- Lommen, Wies;
- van Hees, Hieronymus W. H.;
- Heunks, Leo M. A.;
- Dickhoff, Chris;
- van der Peet, Donald L.;
- Girbes, Armand R. J.;
- Jasper, Jeff R.;
- Malik, Fady I.;
- Stienen, Ger J. M.;
- Hartemink, Koen J.;
- Paul, Marinus A.;
- Ottenheijm, Coen A. C.
Publication type:
Article
Diaphragm Muscle Fiber Weakness in Pulmonary Hypertension.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2011, v. 183, n. 10, p. 1411, doi. 10.1164/rccm.201003-0354OC
By:
- de Man, Frances S.;
- van Hees, Hieronymus W. H.;
- Handoko, M. Louis;
- Niessen, Hans W.;
- Schalij, Ingrid;
- Humbert, Marc;
- Dorfmüller, Peter;
- Mercier, Olaf;
- Bogaard, Harm-Jan;
- Postmus, Piet E.;
- Westerhof, Nico;
- Stienen, Ger J. M.;
- van der Laarse, Willem J.;
- Vonk-Noordegraaf, Anton;
- Ottenheijm, Coen A. C.
Publication type:
Article
Activation of the ubiquitin-proteasome pathway in the diaphragm in chronic obstructive pulmonary disease.
Published in:
2006
By:
- Ottenheijm CAC;
- Heunks LMA;
- Li Y;
- Jin B;
- Minnaard R;
- van Hees HWH;
- Dekhuijzen PNR;
- Ottenheijm, Coen A C;
- Heunks, Leo M A;
- Li, Yi-Ping;
- Jin, Bingwen;
- Minnaard, Ronnie;
- van Hees, Hieronymus W H;
- Dekhuijzen, P N Richard
Publication type:
journal article
Activation of the Ubiquitin-Proteasome Pathway in the Diaphragm in Chronic Obstructive Pulmonary Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2006, v. 174, n. 9, p. 997, doi. 10.1164/rccm.200605-721OC
By:
- Ottenheijm, Coen A. C.;
- Heunks, Leo M. A.;
- Yi-Ping Li;
- Jin, Bingwen;
- Minnaard, Ronnie;
- van Hees, Hieronymus W. H.;
- Richard Dekhuijzen, P. N.
Publication type:
Article
Diaphragm dysfunction in chronic obstructive pulmonary disease.
Published in:
2005
By:
- Ottenheijm CAC;
- Heunks LMA;
- Sieck GC;
- Zhan W;
- Jansen SM;
- Degens H;
- de Boo T;
- Dekhuijzen PNR;
- Ottenheijm, Coen A C;
- Heunks, Leo M A;
- Sieck, Gary C;
- Zhan, Wen-Zhi;
- Jansen, Suzanne M;
- Degens, Hans;
- de Boo, Theo;
- Dekhuijzen, P N Richard
Publication type:
journal article
Diaphragm Dysfunction in Chronic Obstructive Pulmonary Disease.
Published in:
American Journal of Respiratory & Critical Care Medicine, 2005, v. 172, n. 2, p. 200, doi. 10.1164/rccm.200502-262OC
By:
- Ottenheijm, Coen A. C.;
- Heunks, Leo M. A.;
- Sieck, Gary C.;
- Wen-Zhi Zhan;
- Jansen, Suzanne M.;
- Degens, Hans;
- de Boo, Theo;
- Dekhuijzen, P. N. Richard
Publication type:
Article
Acute and chronic tirasemtiv treatment improves in vivo and in vitro muscle performance in actin-based nemaline myopathy mice.
Published in:
Human Molecular Genetics, 2021, v. 30, n. 14, p. 1305, doi. 10.1093/hmg/ddab112
By:
- Winter, Josine M de;
- Gineste, Charlotte;
- Minardi, Elisa;
- Brocca, Lorenza;
- Rossi, Maira;
- Borsboom, Tamara;
- Beggs, Alan H;
- Bernard, Monique;
- Bendahan, David;
- Hwee, Darren T;
- Malik, Fady I;
- Pellegrino, Maria Antonietta;
- Bottinelli, Roberto;
- Gondin, Julien;
- Ottenheijm, Coen A C
Publication type:
Article
Muscle weakness in TPM3-myopathy is due to reduced Ca<sup>2+</sup>-sensitivity and impaired acto-myosin cross-bridge cycling in slow fibres.
Published in:
Human Molecular Genetics, 2015, v. 24, n. 22, p. 6278, doi. 10.1093/hmg/ddv334
By:
- Yuen, Michaela;
- Cooper, Sandra T.;
- Marston, Steve B.;
- Nowak, Kristen J.;
- McNamara, Elyshia;
- Mokbel, Nancy;
- Ilkovski, Biljana;
- Ravenscroft, Gianina;
- Rendu, John;
- de Winter, Josine M.;
- Klinge, Lars;
- Beggs, Alan H.;
- North, Kathryn N.;
- Ottenheijm, Coen A. C.;
- Clarke, Nigel F.
Publication type:
Article
A bright light on myosin to study skeletal muscle relaxation.
Published in:
Journal of Physiology, 2020, v. 598, n. 22, p. 5001, doi. 10.1113/JP280664
By:
- Galli, Ricardo A.;
- Ottenheijm, Coen A. C.
Publication type:
Article
End‐diastolic force pre‐activates cardiomyocytes and determines contractile force: role of titin and calcium.
Published in:
Journal of Physiology, 2019, v. 597, n. 17, p. 4521, doi. 10.1113/JP277985
By:
- Najafi, Aref;
- de Locht, Martijn;
- Schuldt, Maike;
- Schönleitner, Patrick;
- Willigenburg, Menne;
- Bollen, Ilse;
- Goebel, Max;
- Ottenheijm, Coen A. C.;
- der Velden, Jolanda;
- Helmes, Michiel;
- Kuster, Diederik W. D.
Publication type:
Article
Training one type of striated muscle to counteract failure of another type.
Published in:
Journal of Physiology, 2012, v. 590, n. 6, p. 1307, doi. 10.1113/jphysiol.2012.228569
By:
- Stienen, Ger J. M.;
- Ottenheijm, Coen A. C.
Publication type:
Article
New Insights into the Structural Roles of Nebulin in Skeletal Muscle.
Published in:
Journal of Biomedicine & Biotechnology, 2010, p. 1, doi. 10.1155/2010/968139
By:
- Ottenheijm, Coen A. C.;
- Granzier, Henk
Publication type:
Article

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