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- Title
Body mass index and HER-2 overexpression in breast cancer patients over 50 years of age.
- Authors
Van Mieghem, T.; Leunen, K.; Pochet, N.; De Moor, B.; De Smet, F.; Amant, F.; Berteloot, P.; Timmerman, D.; Vanden Bempt, I.; Drijkoningen, R.; Wildiers, H.; Paridaens, R.; Smeets, A.; Hendrickx, W.; Van Limbergen, E.; Christiaens, M. R.; Vergote, I.; Neven, P.
- Abstract
Purpose In breast cancer, in vitro as well as in vivo experiments have shown an inverse relationship between HER-2 and steroid hormone receptors. It is unknown whether circulating estrogens affect HER-2 expression. We hypothesize that the postmenopausal body mass index (BMI) as a surrogate marker for bioavailable estrogens, is inversely associated with HER-2 over-expression. Patients and methods A total of 535 women over age 50 or with known postmenopausal status, with a unilateral,not previously treated, operable breast cancer were evaluated the evening prior to surgery for bodyweight, height, abdominal and hip circumference over a 3 years period. Waist-to-hip ratio (WHR) and BMI were calculated. HER-2, estrogen receptor and progesterone receptor staining was done by immunohistochemistry. All tumours with DAKO 2+ staining were submitted for HER-2 detection by FISH analysis. HER-2 was defined as positive if DAKO 3+ or FISH positive. We assessed the frequency of HER-2 positivity in each of 6 quantiles for all parameters of body composition and tested for a trend in HER-2 expression across the 6 quantiles. Furthermore, we investigated whether BMI contributed, together with other known predictors for HER-2, in a standard multivariate logistic regression model that predicts HER-2 overexpression. Results There is a decrease in HER-2 over-expression per increasing quantile of BMI. In a multivariate model-including both steroid receptors-BMI remains an independent predictor for HER-2 over-expression. Conclusion In women over age 50 or with known postmenopausal status with an operable breast cancer, there is an inverse association between BMI and HER-2 over-expression.
- Subjects
BODY mass index; BREAST cancer patients; HER2 gene; GENE expression; STEROID receptors; HER2 protein; CANCER in women; POSTMENOPAUSE; OBESITY
- Publication
Breast Cancer Research & Treatment, 2007, Vol 106, Issue 1, p127
- ISSN
0167-6806
- Publication type
Article
- DOI
10.1007/s10549-006-9474-7