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- Title
Effect of Choto-san, a Kampo medicine, on impairment of passive avoidance performance in senescence accelerated mouse (SAM).
- Authors
Yutaka Mizushima; Shin Kan; Satoshi Yoshida; Yoshifumi Irie; Yukitomo Urata
- Abstract
Effect of Choto-san (TJ47), a Kampo medicine, on impairment of learning performance was evaluated by means of a step-through passive avoidance task in SAMP8 mice, a senescence-prone substrain. Tokishakuyaku-san (TJ23), another Kampo medicine, was also employed for comparison. SAMP8 mice at the age of 1012 months showed a poorer passive avoidance response than SAMR1 mice, a senescence-resistant substrain, in the memory-retention test, but not in the memory-acquisition test. Improved response in the memory-retention test was observed in SAMP8 mice treated with TJ47, and almost equal degree of improvement was also observed after treatment with TJ23. These results suggest that a long-term administration of Choto-san could improve to some extent the impairment of memory caused by aging. Copyright © 2003 John Wiley & Sons, Ltd.
- Subjects
JAPANESE herbal medicine; MICE; MEMORY; AGING; LEARNING disabilities; USEFUL plants
- Publication
Phytotherapy Research, 2003, Vol 17, Issue 5, p542
- ISSN
0951-418X
- Publication type
Article
- DOI
10.1002/ptr.1193