We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Effects of lanthanum carbonate and calcium carbonate on fibroblast growth factor 23 and hepcidin levels in chronic hemodialysis patients.
- Authors
Chang, Yu-Ming; Tsai, Shih-Ching; Shiao, Chih-Chung; Liou, Hung-Hsiang; Yang, Chuan-Lan; Tung, Nai-Yu; Hsu, Kua-Sui; Chen, I-Ling; Liu, Mei-Chyn; Kao, Jsun-Liang; Jhen, Rong-Na; Huang, Ya-Ting
- Abstract
Background: Phosphate binders have an impact on fibroblast growth factor 23 (FGF23); however, the effect of phosphate binders on serum hepcidin has not been explored. We conducted a 24-week multicenter randomized controlled trial to investigate the effects of lanthanum carbonate or calcium carbonate monotherapy on serum phosphate, FGF23, and hepcidin levels in chronic hemodialysis patients. Methods: Forty-six patients were recruited, and daily dietary phosphorus was controlled between 600-800 mg. Serum calcium, phosphate, albumin, alkaline phosphatase (ALP), FGF23, intact parathyroid hormone (iPTH), hepcidin, high-sensitivity CRP (hsCRP), 25(OH)D, 1,25(OH)D, fetuin-A, and osteopontin were checked as scheduled. Results: Twenty -five patients completed the study. Mean serum FGF23 level was significantly decreased after a 24-week treatment with lanthanum (8677.5 ± 7490.0 vs. 4692.8 ± 5348.3 pg/mL, p = 0.013, n = 13), but not with calcium ( n = 12). The reduction of serum hepcidin in lanthanum group was positively correlated with the decrement of serum phosphate ( r = 0.631, p = 0.021) and serum hsCRP ( r = 0.670, p = 0.012) levels, respectively. Serum ALP, iPTH, vitamin D, fetuin-A, and osteopontin revealed no significant inter- or intragroup differences. Conclusions: In summary, a decrease in serum FGF23 levels and a trend of decline in hepcidin levels were observed only in lanthanum group.
- Subjects
KIDNEY diseases; HEMODIALYSIS patients; HEMODIALYSIS; ALKALINE phosphatase; CALCIUM carbonate; SERUM
- Publication
Clinical & Experimental Nephrology, 2017, Vol 21, Issue 5, p908
- ISSN
1342-1751
- Publication type
Article
- DOI
10.1007/s10157-016-1362-9