We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Incidence of chemotherapy-induced peripheral neuropathy within 12 weeks of starting neurotoxic chemotherapy for multiple myeloma or lymphoma: a prospective, single-center, observational study.
- Authors
Ajewole, Veronica B.; Cox, James E.; Swan, Joshua T.; Chikermane, Soumya G.; Lamoth, Beverly; Iso, Tomona; Okolo, Laura O.; Ford, Christen L.; Schneider, Amy M.; Hobaugh, Eleanor C.; Baker, Kelty R.
- Abstract
<bold>Purpose: </bold>Chemotherapy-induced peripheral neuropathy (CIPN) may necessitate chemotherapy dose reduction, delay, or discontinuation. This pilot study tested feasibility of patient enrollment, CIPN screening, and data collection in cancer patients for a future clinical study that will assess the safety and efficacy of an intervention that may prevent CIPN.<bold>Methods: </bold>This prospective, observational, single-center, pilot study included adults with newly diagnosed lymphoma or multiple myeloma receiving neurotoxic chemotherapy. Patients were enrolled between September 2016 and February 2017. The Functional Assessment of Cancer Therapy/Gynecologic Oncology Group-Neurotoxicity (FACT/GOG-Ntx) questionnaire was completed by patients at 3 time points: baseline, week 6, and week 12. The primary outcome was change in the neurotoxicity score between these time points.<bold>Results: </bold>Of 33 patients approached for consent, 28 (85%) provided consent and were enrolled. The FACT/GOG-Ntx questionnaire was completed by 28 (100%) at baseline, 25 (89%) at week 6, and 24 (86%) at week 12. Average (standard deviation) neurotoxicity scores were 36.5 (6.6) at baseline, 34.0 (8.3) at week 6, and 30.6 (7.6) at week 12. Neurotoxicity scores changed from baseline by - 2.7 points (95% CI - 5.5 to 0.1; p = 0.061) at week 6 and - 6.0 points (95% CI - 5.6 to - 0.8; p = 0.012) at week 12. Clinically meaningful declines (decrease of > 10% from baseline) in neurotoxicity score were detected in 36% (9 of 25) at week 6 and in 67% (16 of 24) at week 12.<bold>Conclusion: </bold>Sixty-seven percent of patients experienced clinically significant CIPN within 12 weeks of starting chemotherapy. Feasibility metrics for enrollment, consent, CIPN assessment, and follow-up were met.
- Subjects
MULTIPLE myeloma; PERIPHERAL neuropathy; CANCER chemotherapy; SCIENTIFIC observation; FUNCTIONAL assessment
- Publication
Supportive Care in Cancer, 2020, Vol 28, Issue 4, p1901
- ISSN
0941-4355
- Publication type
journal article
- DOI
10.1007/s00520-019-05006-6