We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Baseline Repeated Measures from Controlled Human Exposure Studies: Associations between Ambient Air Pollution Exposure and the Systemic Inflammatory Biomarkers IL-6 and Fibrinogen.
- Authors
Thompson, Aaron M .S.; Zanobetti, Antonella; Silverman, Frances; Schwartz, Joel; Coull, Brent; Urch, Bruce; Speck, Mary; Brook, Jeffrey R.; Manno, Michael; Gold, Diane R.
- Abstract
Introduction: Systemic inflammation may be one of the mechanisms mediating the association between ambient air pollution and cardiovascular morbidity and mortality. Interleukin-6 (IL-6) and fibrinogen are biomarkers of systemic inflammation that are independent risk factors for cardiovascular disease. Objective: We investigated the association between ambient air pollution and systemic inflammation using baseline measurements of IL-6 and fibrinogen from controlled human exposure studies. Methods: In this retrospective analysis we used repeated-measures data in 45 nonsmoking subjects. Hourly and daily moving averages were calculated for ozone, nitrogen dioxide, sulfur dioxide, and particulate matter ⩽ 2.5 μm in aerodynamic diameter (PM2.5). Linear mixed-model regression determined the effects of the pollutants on systemic IL-6 and fibrinogen. Effect modification by season was considered. Results: We observed a positive association between IL-6 and O3 [0.31 SD per O3 interquartile range (IQR); 95% confidence interval (CI), 0.08-0.54] and between IL-6 and SO2 (0.25 SD per SO2 IQR; 95% CI, 0.06-0.43). We observed the strongest effects using 4-day moving averages. Responses to pollutants varied by season and tended to be higher in the summer, particularly for O3 and PM2.5. Fibrinogen was not associated with pollution. Conclusions: This study demonstrates a significant association between ambient pollutant levels and baseline levels of systemic IL-6. These findings have potential implications for controlled human exposure studies. Future research should consider whether ambient pollution exposure before chamber exposure modifies IL-6 response.
- Subjects
AIR pollution; HEALTH; CARDIOVASCULAR disease related mortality; INTERLEUKIN-6; FIBRINOGEN; INFLAMMATORY mediators; RETROSPECTIVE studies; PHYSIOLOGICAL effects of ozone; NITROGEN dioxide; PHYSIOLOGICAL effects of sulfur dioxide; PARTICULATE matter
- Publication
Environmental Health Perspectives, 2010, Vol 118, Issue 1, p120
- ISSN
0091-6765
- Publication type
Article
- DOI
10.1289/ehp.0900550