We found a match
Your institution may have rights to this item. Sign in to continue.
- Title
Management of Patients Treated with Direct Oral Anticoagulants in Clinical Practice and Challenging Scenarios.
- Authors
Lucà, Fabiana; Oliva, Fabrizio; Abrignani, Maurizio Giuseppe; Di Fusco, Stefania Angela; Parrini, Iris; Canale, Maria Laura; Giubilato, Simona; Cornara, Stefano; Nesti, Martina; Rao, Carmelo Massimiliano; Pozzi, Andrea; Binaghi, Giulio; Maloberti, Alessandro; Ceravolo, Roberto; Bisceglia, Irma; Rossini, Roberta; Temporelli, Pier Luigi; Amico, Antonio Francesco; Calvanese, Raimondo; Gelsomino, Sandro
- Abstract
It is well established that direct oral anticoagulants (DOACs) are the cornerstone of anticoagulant strategy in atrial fibrillation (AF) and venous thromboembolism (VTE) and should be preferred over vitamin K antagonists (VKAs) since they are superior or non-inferior to VKAs in reducing thromboembolic risk and are associated with a lower risk of intracranial hemorrhage (IH). In addition, many factors, such as fewer pharmacokinetic interactions and less need for monitoring, contribute to the favor of this therapeutic strategy. Although DOACs represent a more suitable option, several issues should be considered in clinical practice, including drug–drug interactions (DDIs), switching to other antithrombotic therapies, preprocedural and postprocedural periods, and the use in patients with chronic renal and liver failure and in those with cancer. Furthermore, adherence to DOACs appears to remain suboptimal. This narrative review aims to provide a practical guide for DOAC prescription and address challenging scenarios.
- Subjects
ORAL medication; ANTICOAGULANTS; CEREBRAL embolism &; thrombosis; CHRONIC kidney failure; ATRIAL fibrillation; FIBRINOLYTIC agents
- Publication
Journal of Clinical Medicine, 2023, Vol 12, Issue 18, p5955
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm12185955