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- Title
Adipose Tissue Stem Cells for Therapy: An Update on the Progress of Isolation, Culture, Storage, and Clinical Application.
- Authors
Chu, Dinh-Toi; Nguyen Thi Phuong, Thuy; Tien, Nguyen Le Bao; Tran, Dang Khoa; Minh, Le Bui; Thanh, Vo Van; Gia Anh, Pham; Pham, Van Huy; Thi Nga, Vu
- Abstract
Adipose tissue stem cells (ASCs), known as multipotent stem cells, are most commonly used in the clinical applications in recent years. Adipose tissues (AT) have the advantage in the harvesting, isolation, and expansion of ASCs, especially an abundant amount of stem cells compared to bone marrow. ASCs can be found in stromal vascular fractions (SVF) which are easily obtained from the dissociation of adipose tissue. Both SVFs and culture-expanded ASCs exhibit the stem cell characteristics such as differentiation into multiple cell types, regeneration, and immune regulators. Therefore, SVFs and ASCs have been researched to evaluate the safety and benefits for human use. In fact, the number of clinical trials on ASCs is going to increase by years; however, most trials are in phase I and II, and lack phase III and IV. This systemic review highlights and updates the process of the harvesting, characteristics, isolation, culture, storage, and application of ASCs, as well as provides further directions on the therapeutic use of ASCs.
- Subjects
ADIPOSE tissues; STEM cell treatment; MULTIPOTENT stem cells; BONE marrow cells; STEM cells
- Publication
Journal of Clinical Medicine, 2019, Vol 8, Issue 10, p917
- ISSN
2077-0383
- Publication type
Article
- DOI
10.3390/jcm8070917