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- Title
Silicon as a Functional Meat Ingredient Improves Jejunal and Hepatic Cholesterol Homeostasis in a Late-Stage Type 2 Diabetes Mellitus Rat Model.
- Authors
Hernández-Martín, Marina; Garcimartín, Alba; Bocanegra, Aránzazu; Redondo-Castillejo, Rocío; Quevedo-Torremocha, Claudia; Macho-González, Adrián; García Fernández, Rosa Ana; Bastida, Sara; Benedí, Juana; Sánchez-Muniz, Francisco José; López-Oliva, María Elvira
- Abstract
Silicon included in a restructured meat (RM) matrix (Si-RM) as a functional ingredient has been demonstrated to be a potential bioactive antidiabetic compound. However, the jejunal and hepatic molecular mechanisms by which Si-RM exerts its cholesterol-lowering effects remain unclear. Male Wistar rats fed an RM included in a high-saturated-fat high-cholesterol diet (HSFHCD) combined with a low dose of streptozotocin plus nicotinamide injection were used as late-stage type 2 diabetes mellitus (T2DM) model. Si-RM was included into the HSFHCD as a functional food. An early-stage TD2M group fed a high-saturated-fat diet (HSFD) was taken as reference. Si-RM inhibited the hepatic and intestinal microsomal triglyceride transfer protein (MTP) reducing the apoB-containing lipoprotein assembly and cholesterol absorption. Upregulation of liver X receptor (LXRα/β) by Si-RM turned in a higher low-density lipoprotein receptor (LDLr) and ATP-binding cassette transporters (ABCG5/8, ABCA1) promoting jejunal cholesterol efflux and transintestinal cholesterol excretion (TICE), and facilitating partially reverse cholesterol transport (RCT). Si-RM decreased the jejunal absorptive area and improved mucosal barrier integrity. Consequently, plasma triglycerides and cholesterol levels decreased, as well as the formation of atherogenic lipoprotein particles. Si-RM mitigated the dyslipidemia associated with late-stage T2DM by Improving cholesterol homeostasis. Silicon could be used as an effective nutritional approach in diabetic dyslipidemia management.
- Subjects
ATP-binding cassette transporters; TYPE 2 diabetes; LABORATORY rats; SILICON compounds; NICOTINAMIDE; CHOLESTEROL; HOMEOSTASIS; HIGH cholesterol diet
- Publication
Foods, 2024, Vol 13, Issue 12, p1794
- ISSN
2304-8158
- Publication type
Article
- DOI
10.3390/foods13121794