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- Title
Pro-inflammatory Cytokine Expression of Spleen Dendritic Cells in Mouse Toxoplasmosis.
- Authors
Ho-Woo Nam; Hye-Jin Ahn; Hyun-Jong Yang
- Abstract
Dendritic cells have been known as a member of strong innate immune cells against infectious organelles. In this study, we evaluated the cytokine expression of splenic dendritic cells in chronic mouse toxoplasmosis by tissue cyst- forming Me49 strain and demonstrated the distribution of lymphoid dendritic cells by fluorescence-activated cell sorter (FACS). Pro-inflammatory cytokines, such as IL-1α, IL-1 β, IL-6, and IL-10 increased rapidly at week 1 post-infection (PI) and peaked at week 3 PI. Serum IL-10 level followed the similar patterns. FACS analysis showed that the number of CD8a+V CD11c+ splenic dendritic cells increased at week 1 and peaked at week 3 PI. In conclusion, mouse splenic dendritic cells showed early and rapid cytokine changes and may have important protective roles in early phases of routine toxoplasmosis.
- Subjects
DENDRITIC cells; GENE expression; CELLULAR immunity; ORGANELLES; CYTOKINES; TOXOPLASMOSIS in animals; MICE; MICROBIAL cysts; FLUORESCENCE
- Publication
Korean Journal of Parasitology, 2011, Vol 49, Issue 2, p109
- ISSN
0023-4001
- Publication type
Article
- DOI
10.3347/kjp.2011.49.2.109