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- Title
Vitamin D deficiency is associated with diagnosis and severity of childhood atopic dermatitis.
- Authors
Wang, Susan Shuxin; Hon, Kam Lun; Kong, Alice Pik‐shan; Pong, Henry Nga‐hin; Wong, Gary Wing‐kin; Leung, Ting Fan
- Abstract
Background Recent studies implicated the importance of vitamin D in innate immune defense and pathogenesis of allergic diseases. However, the impact of vitamin D deficiency on atopic dermatitis ( AD) diagnosis and severity remains unclear. This case-control study investigated such relationship in Hong Kong Chinese children. Methods Serum 25-hydroxyvitamin D [25( OH)D] levels of 498 AD children and 328 non-allergic controls were measured by immunoassay. Subjects were categorized into deficient (<25 n m), insufficient (25-49.9 n m), and sufficient (≥50 n m) groups. Short-term and long-term AD severity was evaluated by physician-diagnosed SCORing Atopic Dermatitis ( SCORAD) and Nottingham Eczema Severity Score ( NESS), respectively. Atopy biomarkers were also measured for analysis. Results The mean (s.d.) serum 25( OH) D levels in AD patients and controls were 28.9 (15.3) and 34.2 (14.5) n m, respectively (p < 0.001). More patients had serum 25( OH)D levels <25 n m than controls (47.8% vs. 26.6%). AD severity as indicated by both SCORAD and NESS showed inverse associations with serum 25( OH)D levels (respective p = 3.6 × 10−4 and 0.004 when adjusted for age, sex, month of assessment, and immunoassay batch as covariates). Vitamin D-deficient patients (3.08 ± 0.76) had higher logarithm-transformed total IgE than those with insufficient (2.74 ± 0.69) and sufficient (2.72 ± 0.72) serum 25( OH) D levels (p < 0.001). The proportion of subjects with elevated Ig E was higher in vitamin D-deficient (43.2%) than vitamin D-sufficient (20.0%) groups. Conclusions Vitamin D deficiency and insufficiency are prevalent in Hong Kong Chinese children. Vitamin D deficiency is associated with childhood AD and high total Ig E. Serum 25( OH) D levels correlate inversely with both long- and short-term AD severity.
- Subjects
VITAMIN D deficiency; ATOPIC dermatitis; ALLERGY in children; IMMUNE response; IMMUNOASSAY
- Publication
Pediatric Allergy & Immunology, 2014, Vol 25, Issue 1, p30
- ISSN
0905-6157
- Publication type
Article
- DOI
10.1111/pai.12167