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- Title
Characterization of the common acute lymphoblastic leukaemia antigen (CD10) as an activation molecule on mature human B cells.
- Authors
Kiyokawa, N.; Kokai, Y.; Ishimoto, K.; Fujita, H.; Fujimoto, J.; Hata, J.-I.
- Abstract
Distinct expression pattern of CD10 molecules during B cell activation was analysed Using in vivo and in vitro systems. By two-colour flowcytometrical analysis, CD10 was found to be expressed at a specific stage of in vivo activating B cells. The expression of CD10 during B cell activation appeared to be unique from that of other activation-related B cell antigens including L29. MA6, OKT9 and OKT10. Although the expression of CD10 was associated with that of the activation-related B cell antigens, CD10+ B cells could be separated in the distinct fractions to those expressing other activation-related B cell antigens when fractionated by cell gravity. In particular, certain CD10+ B cells were detected positive for the resting B cell antigen, L30. In vitro studies revealed that CD10- B cells arose from CD10+ B cells at an early step of B cell activation, and disappeared lately when activated by Staphylococcus aureus Cowan I. Collectively. CD10 was an antigen transiently expressed at an early phase of B cell activation process. Expression of CD10 and other antigens on Burkitt's lymphomas (15 cases) was studied next. All cases were CD10-,and 87% (13 cases) were also 1.30+. In addition, six of CD10+ L30+ eases were L29+. This observation suggested that Burkitt's lymphomas were phenotypically similar to the B cells at an early phase of activation, those expressing CD10 and L30, simultaneously. The present study has dissected a precise expression pattern of CD10 on mature B cell activation in vitro and in vivo, and could be implicated for the histogenesis of one of the poorly characterized B cell lymphoma, namely Burkitt's lymphoma.
- Subjects
B cells; LYMPHOMAS; IMMUNOGLOBULINS; LYMPHOBLASTIC leukemia; LYMPHOPROLIFERATIVE disorders; STAPHYLOCOCCUS aureus
- Publication
Clinical & Experimental Immunology, 1990, Vol 79, Issue 3, p322
- ISSN
0009-9104
- Publication type
Article